Intoxicação experimental em coelhos por Mascagnia sp (Malpighiaceae) procedente do Estado de Santa Catarina

Tokarnia, Carlos Hubinger; Gava, Aldo; Brito, Marilene de Farias; Bezerra, Pedro Soares; Oliveira, Krishna Düro de

doi:10.1590/s0100-736x1998000200004

Cited by 5 publications

(1 citation statement)

References 1 publication

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Nestas o quadro observado caracteriza-se pelo súbito aparecimento dos sinais clínicos, quando animais aparentemente sadios começam a debater-se, fazem movimentos bruscos, violentos e desordenados, caem em decúbito lateral e logo morrem, como foi relatado nas intoxicações experimentais em coelhos por Palicourea marcgravii (Pacheco & Carneiro 1932, Peixoto et al 1987, P. juruana , P. grandiϔlora, , Pseudocalymma elegans (Tavares et al 1974), Arrabidea japurensis (Döbereiner & Tokarnia 1983), A. bilabiata (Döbereiner et al 1984), Mascagnia pubiϔlora (Döbereiner et al 1986), Mascagnia aff. rigida (Tokarnia et al 1985), M. rigida ) e M. exotropica (Tokarnia et al 1998).…”

Section: Discussionunclassified

Intoxicação experimental por Metternichia princeps (Solanaceae) em coelhos

et al. 2012

Self Cite

View full text Add to dashboard Cite

Metternichia princeps, a tree that belongs to the Solanaceae family, occurs in the Atlantic Forest of Brazil, from the state of Rio de Janeiro to Bahia. In the county of Itaguaí, state of Rio de Janeiro, M. princeps was suspected to cause a lethal kidney disease in goats. The poisoning was experimentally reproduced in goats conϐirming the suspicion. Experiments were then performed in rabbits. Leaves of M. princeps were collected in the county of Itaguaí, where the poisoning in goats occurred. Eleven rabbits received the dried plant material, ten received the fresh plant and one rabbit served as control. The dehydrated leaves were ground and mixed with water. Initially the suspension was administered by stomach tube to nine rabbits and caused death of seven of them at doses from 0.125g/kg on. Two rabbits that got sick, but survived at doses of 0.0625g/kg and 0.125g/kg, received doses of 0.5 and 0.25g/kg respectively, two months later and died, indicating that no tolerance to the plant poisoning effects developed. Additionally the dried leaves administered six months after collection to two rabbits at doses of 0.5 and 1g/kg respectively, caused death only of the rabbit that received the dose of 1g/kg, indicating that the stored leaves lost toxicity. Fresh sprouts caused death in three of six rabbits at doses of 1.55g/kg to 3g/kg. Fresh mature leaves caused death in one of four rabbits at the dose of 2g/kg, what suggests that there is no difference in toxicity between mature leaves and sprouts. The dried leaves caused death of rabbits at smaller doses than fresh leaves, what can be explained by the way of administration of the plant; dried leaves were given within a few minutes, whilst fresh leaves were ingested during one or two days, a fact that may inϐluence absorption of the toxic principle. In all experiments with the dried and fresh leaves (sprouts and mature leaves) of M. princeps, liver and heart lesions predominated. The course of the poisoning was peracute to acute. The rabbits became apathetic with pale and cyanotic mucosae and cold ears; they fell down with struggling movements, vocalization and spaced breathing and died. At postmortem examination, the liver was pale with marked hepatic lobules; the other organs were congested and blood vessels were ingurgitated. The histopathological examination revealed as the more important changes in the liver, intense, especially centrilobular congestion, severe swelling of the hepatocytes, and foci of incipient necrosis of hepatocytes. In the heart, beside congestion, small groups of eosiophilic cardiac ϐibers, with nuclear picnosis and vacuolation were found. In the kidney, congestion and swelling of epithelial cells

show abstract

Section: Discussionunclassified

Intoxicação experimental por Metternichia princeps (Solanaceae) em coelhos

et al. 2012

Self Cite

View full text Add to dashboard Cite

show abstract

Detection of monofluoroacetate in Palicourea and Amorimia species

Lee

Cook

Riet-Correa

et al. 2012

Toxicon

View full text Add to dashboard Cite

Use of Herbarium Voucher Specimens To Investigate Phytochemical Composition in Poisonous Plant Research

Cook

Lee

Gardner

et al. 2021

J. Agric. Food Chem.

View full text Add to dashboard Cite

Poisonous plants cause large losses to the livestock industry through death, reduced production efficiency, reproductive dysfunction, and compromised harvesting of rangeland and pasture forages. Research investigating poisonous plants is complex because there are hundreds of genera of toxic plants representing thousands of species. To investigate the effects of poisonous plants on livestock, a clear understanding of the taxonomic identity of the plant and the ability to collect the plant in sufficient quantities for scientific studies is required. Subsequently, the active principles must be defined and investigated in the taxa of interest to better predict risk and make recommendations to reduce losses. Herbaria are collections of preserved plant specimens and are an important resource in poisonous plant research. Voucher specimens have often been used in the identification of the plant for the experimental reproduction of suspected livestock poisoning associated with a spontaneous case. More recently, herbarium specimens have been used to investigate the chemical composition of toxic plants as well as the distribution of different chemotypes over the landscape. The primary purpose of this review is to highlight the chemical analysis of herbarium specimens in poisonous plant research.

show abstract

Intoxicação experimental em coelhos por Mascagnia sp (Malpighiaceae) procedente do Estado de Santa Catarina

Cited by 5 publications

References 1 publication

Intoxicação experimental por Metternichia princeps (Solanaceae) em coelhos

Intoxicação experimental por Metternichia princeps (Solanaceae) em coelhos

Detection of monofluoroacetate in Palicourea and Amorimia species

Use of Herbarium Voucher Specimens To Investigate Phytochemical Composition in Poisonous Plant Research

Contact Info

Product

Resources

About