Os macrófagos na placenta durante o trabalho de parto

Alves, Júlio Augusto Gurgel; Câmara, Lilia Maria Carneiro; Costa, Fabrício da Silva; Rocha, Rebeca Silveira; Araújo, Maria Neile Torres

doi:10.1590/s0100-72032009000200007

Cited by 2 publications

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“…Viral proteins were found inside macrophages (61) abundant in the chorionic villi (62) . One could easily postulate that these innate immune mobile cells were acting as Trojan horses, carrying the virus from the mother to her fetus (63) .…”

Section: Zika Virus: Old and Newly Identified Transmission Modesmentioning

confidence: 99%

Zika virus: what do we know about the viral structure, mechanisms of transmission, and neurological outcomes?

Silva

Souza

2016

Rev. Soc. Bras. Med. Trop.

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The Zika virus epidemic that started in Brazil in 2014 has spread to >30 countries and territories in Latin America, leading to a rapid rise in the incidence of microcephalic newborns and adults with neurological complications. At the beginning of the outbreak, little was known about Zika virus morphology, genome structure, modes of transmission, and its potential to cause neurological malformations and disorders. With the advancement of basic science, discoveries of the mechanisms of strain variability, viral transfer to the fetus, and neurovirulence were published. These will certainly lead to the development of strategies to block vertical viral transmission, neuronal invasion, and pathogenesis in the near future. This paper reviews the current literature on Zika virus infections, with the aim of gaining a holistic insight into their etiology and pathogenesis. We discuss Zika virus history and epidemiology in Brazil, viral structure and taxonomy, old and newly identified transmission modes, and neurological consequences of infection.

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Section: Zika Virus: Old and Newly Identified Transmission Modesmentioning

confidence: 99%

Zika virus: what do we know about the viral structure, mechanisms of transmission, and neurological outcomes?

Silva

Souza

2016

Rev. Soc. Bras. Med. Trop.

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“…Among the most relevant histological findings, the incidence of leukocytes and macrophages at the maternal-fetal interface (Fig. 3-4) may be associated with labor onset (Alves et al 2009). However, although neutrophils are physiologically present during labor, an exacerbated increase in the number of leukocytes in the placenta may indicate a placental infection called placentitis or chorioamnionitis (Machado et al 2012).…”

Section: Discussionmentioning

confidence: 99%

Monitoring periodontal lesions and their effects during pregnancy: microbiological aspects of the oral cavity and amniotic fluid in pregnant ewes

et al. 2023

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Periodontitis affects the teeth supporting tissues, leading to tooth loss and damage to animal health. Evidence in humans suggests that oral microorganisms spread systemically, increasing the risk of pregnancy disorders such as miscarriage, prematurity, and low birth weight. This study aimed to verify whether periodontopathogenic microorganisms reach the transplacental unit, culminating in problems in pregnant ewes. After analyzing the oral cavity, 10 clinically healthy pregnant ewes (OGCH group) and 10 pregnant ewes with periodontitis (OGP group) were selected. The subgingival biofilm was collected for the polymerase chain reaction (PCR) test and amniotic fluid for both the PCR and interleukin (IL) analysis. Peripheral blood was collected for complete blood count, and analyses of IL-6, IL1-β, and tumor necrosis factor-α were performed. Placental fragments were collected to assess the inflammatory changes using optical microscopy. After giving birth, both the ewes and their lambs were weighed. On clinical examination, a positive correlation between bleeding and suppuration (correlation index - CI=0.54), suppuration and marginal gingivitis (CI=0.34), and marginal gingivitis and edema (CI=0.54) was observed. The weights of the ewes (p=0.013) and their respective lambs (p=0.04) in the OGP group were lower than those of their OGCH group counterparts. The hematological analysis revealed that the OGP group ewes showed a slight increase in the mean corpuscular volume (p=0.2447), segmented cells (p=0.3375), and eosinophils (p=0.3823) when compared with the OGCH group ewes, without a statistical difference. Regarding the microorganisms detected in the oral cavity, there was a significant difference between the occurrence of periodontal pockets and the presence of Fusobacterium necrophorum (p=0.0328), Porphyromonas asaccharolytica (p=0.0392), and the Mollicutes class (p=0.0352). Staphylococcus genus (p=0.9107) and Archaea domain (p=0.7245) were detected in the amniotic samples of both groups, without a significant difference, whereas P. asaccharolytica (p=0.2685) was only detected in one sample in the OGCH group. The expression of cytokine IL-6 in the OGP group differed significantly between the prepartum and postpartum periods (p=0.0039); moreover, it differed significantly in the postpartum period between the OGCH and OGP groups (p=0.0198). Histological examination showed a higher percentage of placental changes in the OGP group (70%) than in the OGCH group, such as the presence of macrophages, neutrophils, plasma cells, and multifocal areas of calcification. These results do not corroborate the hypothesis of dissemination of oral microorganisms to the placental unit, suggesting that it constitutes placental isolation in sheep.

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Os macrófagos na placenta durante o trabalho de parto

Cited by 2 publications

References 0 publications

Zika virus: what do we know about the viral structure, mechanisms of transmission, and neurological outcomes?

Zika virus: what do we know about the viral structure, mechanisms of transmission, and neurological outcomes?

Monitoring periodontal lesions and their effects during pregnancy: microbiological aspects of the oral cavity and amniotic fluid in pregnant ewes

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