Fatores associados à densidade mamográfica de mulheres na pós-menopausa

Siqueira, Renata Ferreira Cleto Bittencourt; Sá, Danielle Santos Bezerra; Neto, Aarão Mendes Pinto; Cabello, César; Conde, Délio Marques; Fonsechi‐Carvasan, Gislaine Aparecida

doi:10.1590/s0100-72032004000100007

Cited by 2 publications

(5 citation statements)

References 22 publications

(49 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…have developed a similar study; but such authors evaluated only post-menopausal women, and have not found statistically significant association between age and mammographic density pattern. The authors have explained such finding by the high prevalence of breasts with lower density in the group of women included in their study (24) . Mezzacappa & Mezzacapa Filho have reported that breasts undergo profound physiological changes during the gestational period; glandular differentiation is the main of such changes.…”

Section: R-cc L-ccmentioning

confidence: 96%

“…The present study has also assessed the relationship between breast density and BMI, age, parity and use of HRT. The presence of a high BMI results in greater amount of adipose tissue in the breast and greater number of adipocytes, the cells responsible for the peripheral conversion of cholesterol into estrogen, besides producing several other hormones, which favors the increase in breasts size and decrease of mammographic density (24,25) . Sung et al have evaluated the relationship between BMI and breast constitution, and observed a increase in adipose tissue in the breasts with the increase of BMI (26) .…”

Section: R-cc L-ccmentioning

confidence: 99%

See 1 more Smart Citation

Mammographic density in asymptomatic menopausal women: correlation with clinical and sonographic findings

Álvares

Freitas²,

Jales

et al. 2012

Radiol Bras

View full text Add to dashboard Cite

OBJECTIVE: To evaluate mammographic breast density in asymptomatic menopausal women in correlation with clinical and sonographic findings. MATERIALS AND METHODS: Mammograms and clinical and sonographic findings of 238 asymptomatic patients were retrospectively reviewed in the period from February/2022 to June/2006. The following variables were analyzed: mammographic density patterns, sonographic findings, patients' age, parity, body mass index and use of hormone replacement therapy. RESULTS: Age, parity and body mass index showed a negative correlation with breast density pattern, while use of hormone replacement therapy showed a positive correlation. Supplementary breast ultrasonography was performed in 103 (43.2%) patients. Alterations which could not be visualized at mammography were found in 34 (33%) of them, most frequently in women with breast density patterns 3 and 4. CONCLUSION: The authors concluded that breast density patterns were influenced by age, parity, body mass index and time of hormone replacement therapy. Despite not having found any malignant abnormality in the studied cases, the authors have observed a predominance of benign sonographic abnormalities in women with high breast density patterns and without mammographic abnormalities, proving the relevance of supplementary ultrasonography to identify breast lesions in such patients.

show abstract

Section: R-cc L-ccmentioning

confidence: 96%

Section: R-cc L-ccmentioning

confidence: 99%

Mammographic density in asymptomatic menopausal women: correlation with clinical and sonographic findings

Álvares

Freitas²,

Jales

et al. 2012

Radiol Bras

View full text Add to dashboard Cite

show abstract

“…Notamos que as pacientes com média de IMC = 28,29 tinham mamas mais lipossubstituídas do que aquelas com média de IMC = 24,57. Essa diferença foi signifi cante, o que também foi referido por outros autores 25 .…”

Section: Densidadesunclassified

“…Uma menarca precoce pode estar associada a um início mais rápido nos ciclos ovulatórios e, por isso, a uma exposição vitalícia maior aos hormônios endógenos, a qual pode provocar maior proliferação epitelial 25 . Não encontramos associação signifi cativa entre idade da menarca e densidade mamográfi ca aumentada.…”

Section: Densidadesunclassified

See 1 more Smart Citation

Associação entre os polimorfismos HaeIII e MspI do gene para o receptor alfa de estrogênio e densidade mamográfica em mulheres após a menopausa

Ramos¹,

Kemp

Silva³

2006

Rev. Bras. Ginecol. Obstet.

View full text Add to dashboard Cite

RESUMOObjetivo: Avaliar a presença dos polimorfi smos HaeIII e MspI do gene para o receptor de estrogênio alfa, bem como fatores clínicos e suas possíveis associações com a densidade mamográfi ca em mulheres após a menopausa. Métodos: Foram avaliadas 115 mulheres após a menopausa, não usuárias de terapia hormonal e sem lesão mamária clínica ou mamografi camente identifi cada. A densidade mamográfi ca foi determinada por três observadores independentes, tomando-se como base a classifi cação dos padrões mamográfi cos do ACR-BIRADS ® , 2003 (duas avaliações subjetivas e uma computadorizada -Adobe Photoshop ® 7.0). Amostras de raspado bucal foram obtidas para extração de DNA e em seguida foi realizada uma PCR-RFLP (Polymerase Chain Reation -Restriction Fragment Length Polymorphism) para análise de polimorfi smos presentes no íntron 1 e éxon 1 do gene do REα (HaeIII e MspI). Resultados: O polimorfi smo HaeIII foi encontrado em 43 (37,4%) das 115 mulheres, ao passo que o MspI estava presente em 96 (83,5%) das mesmas. Houve alto grau de concordância entre os três observadores na determinação da densidade mamográfi ca. Trinta e quatro (29,6%) mulheres tinham mamas densas, e 81 (70,4%), mamas lipossubstituídas. Conclusão: Não houve associação entre o polimorfi smo HaeIII do gene para o receptor de estrogênio alfa e densidade mamográfi ca (Fisher = 0,712). Houve associação próxima à signifi cância estatística entre o polimorfi smo MspI e densidade (Fisher = 0,098). Idade, paridade e índice de massa corporal mostraram-se associados com densidade mamográfi ca. PALAVRAS-CHAVE:Receptores estrogênicos; Polimorfi smo genético; Mamografi a; Neoplasias mamárias; Pós menopausa ABSTRACT Purpose: To assess the presence of estrogen receptor gene polymorphisms HaeIII and MspI as well as clinical factors, and their possible associations with high mammographic density in post-menopausal women. Methods: One hundred and fi fteen post-menopausal women, not in use of hormonal therapy and without clinical or mammographic lesions were evaluated. Three independent observers have determined the mammographic density pattern based on the ACR-BIRADS ® 2003 (two subjective and one objective evaluations -Adobe Photoshop 7.0 software). Oral swabs (Cytobrush) were obtained to extract DNA and the polymerase chain reaction -restriction fragment length polymorphism) was performed to assess the presence of polymorphisms in intron 1 and exon 1 from estrogen receptor gene (HaeIII and MspI). Results: The HaeIII polymorphism was found in 43 (37.4%) of the 115 women, while MspI was found in 96 (83.5%) of them. There was a good agreement among determinations of the three observers with regard to mammographic density. Thirty-four (29.6%) women had dense breasts and eighty-one (70.4%) had non-dense breasts. Conclusion: The estrogen receptor gene polymorphism Haelll showed no association with mammographic density (Fisher = 0.712), while the association between estrogen receptor gene polymorphism Mspl and mammographic density was near signifi cance (Fisher = 0.098)...

show abstract

Fatores associados à densidade mamográfica de mulheres na pós-menopausa

Cited by 2 publications

References 22 publications

Mammographic density in asymptomatic menopausal women: correlation with clinical and sonographic findings

Mammographic density in asymptomatic menopausal women: correlation with clinical and sonographic findings

Associação entre os polimorfismos HaeIII e MspI do gene para o receptor alfa de estrogênio e densidade mamográfica em mulheres após a menopausa

Contact Info

Product

Resources

About