2013
DOI: 10.1590/s0100-69912013000600009
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Abstract: Results ResultsResults Results: The mean follow-up time was 41.9 months. Hemizygous deletion was detected in 18 patients (33.9%), while the homozygous one was present in three (5.6%). Deletion was present in approximately 40% of the analyzed cases. Monosomy and trisomy were detected in nine (17%) and two patients (3.8%), respectively. In 21 patients (39.6%) the analysis of the PTEN gene by in situ hybridization was normal. There were no statistically significant differences in overall (p = 0.468) and disease-f… Show more

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Cited by 5 publications
(1 citation statement)
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“…de Campos, et al . reported that the deletion of PTEN in RCC was detected with a frequency of approximately 40% via fluorescent in situ hybridization and that its presence did not indicate lower survival rates [44]. Thus, PTEN mutations and loss of heterozygosity were demonstrated to play a key role in the etiology of various cancers and were associated with late-stage diseases [45].…”
Section: Discussionmentioning
confidence: 99%
“…de Campos, et al . reported that the deletion of PTEN in RCC was detected with a frequency of approximately 40% via fluorescent in situ hybridization and that its presence did not indicate lower survival rates [44]. Thus, PTEN mutations and loss of heterozygosity were demonstrated to play a key role in the etiology of various cancers and were associated with late-stage diseases [45].…”
Section: Discussionmentioning
confidence: 99%