Vitamina D e cicatrização de pele: estudo prospectivo, duplo-cego, placebo controlado na cicatrização de úlceras de perna

Abstract

Patients with leg ulcers have more vitamin D deficiency. No difference in the ulcer characteristics was noted between those with and without vitamin D deficiency. There was a trend toward a better healing in those with vitamin D reposition.

Effects and associations of nutrition in patients with venous leg ulcers: A systematic review

“…Eight studies were cross-sectional (Abbade, Lastoria, & Rollo Hde, 2011;Abbade et al, 2005;Burkievcz et al, 2012;Finlayson, Edwards, & Courtney, 2009;McDaniel, Kemmner, & Rusnak, 2015;Tobon, Whitney, & Jarrett, 2008;Vines, Gemayel, & Christenson, 2013;Wojcik, Atkins, & Mager, 2011). Three were case-control studies (Durmazlar, Akgul, & Eskioglu, 2009;Legendre et al, 2008;Szewczyk et al, 2008) and three were quasi-experimental studies (Burkiewicz et al, 2012;De Franciscis et al, 2015;Serra et al, 2016).…”

“…The length of follow-up of the four intervention studies ranged from 28 days to 12 months (Burkiewicz et al, 2012;De Franciscis et al, 2015;Raffoul et al, 2006;Serra et al, 2016). The follow-up period for the remaining studies ranged from data collected at a single time point to 7 years.…”

“…Ten studies were located in Europe (Milic et al, 2009) (Apollonio et al, 2016;De Franciscis et al, 2015;Hjerppe et al, 2010;Krejner et al, 2016;Legendre et al, 2008;Raffoul et al, 2006;Serra et al, 2016;Szewczyk et al, 2008;Vines et al, 2013), one in Turkey (Durmazlar et al, 2009), four in South America (Abbade et al, 2005(Abbade et al, , 2011Burkievcz et al, 2012;Burkiewicz et al, 2012), one in Australia (Finlayson et al, 2009) and four in North America (Labropoulos et al, 2012;McDaniel et al, 2015;Tobon et al, 2008;Wojcik et al, 2011).…”

“…There was a wide variety of healthcare settings, the most common being outpatient clinics (Abbade et al, 2005(Abbade et al, , 2011Burkievcz et al, 2012;Burkiewicz et al, 2012;Hjerppe et al, 2010;Tobon et al, 2008). Three studies were set in hospitals (Durmazlar et al, 2009;Raffoul et al, 2006;Vines et al, 2013).…”

“…For the Cochrane risk of bias assessment, most studies only satisfactorily met criteria for the incomplete outcome data and selective reporting categories due to their observational design. Of the four studies that contained an intervention, three had employed quasi-experimental designs that lacked randomization (Burkiewicz et al, 2012;De Franciscis et al, 2015;Serra et al, 2016). Only two studies reported adequate allocation concealment (Burkiewicz et al, 2012;De Franciscis et al, 2015).…”