BackgroundThe number of malignancies increased alarmingly. Surgery constitutes one of the
most efficient therapeutic modalities for the treatment of solid tumors. The
neoplastic implant in surgical wound is a complication whose percentage of
occurrence reported in the literature is variable, but sets with high morbidity
and therapeutic difficulties. Protecting the wound is one of the recommended
principles of oncologic surgery.AimTo evaluate the influence of wound protection in the development of tumor
implantation.MethodsSarcoma 180 tumor cells were used, with intraperitoneal inoculation in Swiss mice.
After the establishment of neoplastic ascites, animals were randomized into two
groups of 10, each group consisting of five males and five females. In both
groups, laparotomy and manipulation of intra-abdominal organs was performed. In a
group laparotomy was performed using the protection of the abdominal wound and the
other group without it. On the 9th postoperative day macroscopic
evaluation of the operative scar was performed, which was later removed for
microscopic evaluation.ResultsThere was microscopic infiltration of tumor cells in the wound of all animals.
However, the group that held the protection, infiltration was less intense when
compared to the group without it. The infiltration was also more severe in females
than in males of the same group.ConclusionTumor infiltration into the wound was more intense in the group in which the
protection of the surgical site was not performed, and in females when compared to
males of the same group.