1999
DOI: 10.1590/s0100-69911999000500003
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Abstract: A cicatrização da pele e do intestino podem ser influenciadas pela elevação da bilirrubina. Com o objetivo de avaliar o possível efeito da icterícia obstrutiva sobre a sutura da pele e de anastomose jejunal, foram estudados 32 ratos, divididos em quatro grupos (n=8) e acompanhados em períodos pós-operatórios de sete e 14 dias. Todos os animais foram submetidos a laparotomia e anastomose jejunal. Os grupos 1 e 2 serviram como controle dos grupos 3 e 4, os quais foram submetidos a ligadura do ducto biliopancreát… Show more

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Cited by 10 publications
(20 citation statements)
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“…There is evidence in the literature that jaundice interferes negatively with the healing process [6][7][8] . However, this was not evident in the present study when comparing groups L vs. M and LK vs. M, whether on histological analysis or tensile strength analysis of the sutured bowel segment.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…There is evidence in the literature that jaundice interferes negatively with the healing process [6][7][8] . However, this was not evident in the present study when comparing groups L vs. M and LK vs. M, whether on histological analysis or tensile strength analysis of the sutured bowel segment.…”
Section: Discussionmentioning
confidence: 99%
“…There is evidence that obstructive jaundice contributes to poor outcomes of anastomotic bowel healing [6][7][8] . In 1997, Brazilian investigators reviewed the literature on the subject and, after presenting data from their own experimental procedure, reported possible mechanisms responsible for failed healing in jaundiced conditions.…”
Section: Introductionmentioning
confidence: 99%
“…The choice of hydrocortisone dose for this study was defined on previous studies that verified that 10 mg/kg/day is the minimal concentration necessary to affect wound healing, and it is also proportional to doses prescribed in several clinical treatments 10,11 . Following other authors 7,13 , the administration of the drug was initiated in the preoperative phase and continued until the day the animals were killed.…”
Section: Upon Histological Assessment It Was Verified Thatmentioning
confidence: 99%
“…The need for further studies in order to understand the effects of corticoids on skin healing motivated this project, which is part of a line of research on wound healing [10][11][12] . The objective of this study was to compare the skin wound healing resistance after local and systemic administration of hydrocortisone in distinct postoperative periods.…”
Section: Introductionmentioning
confidence: 99%
“…Atuando como antiinflamatório, eles levariam à diminuição dos mediadores responsáveis pela proliferação de fibroblastos, reduzindo assim a produção de colágeno (7) . (8)(9)(10) , o objetivo do presente trabalho foi avaliar o efeito do ácido ascórbico e da hidrocortisona sobre a cicatrização anastomótica intestinal de ratos em distintos períodos do pós-operatório. …”
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