2013
DOI: 10.1590/s0100-40422013000800019
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Abstract: Recebido em 8/11/12; aceito em 25/4/13; publicado na web em 13/6/13 VALIDATION OF THE ACETONITRILE-FREE ANALYTICAL METHOD FOR MICROCYSTIN ANALYSIS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY. Blooms of cyanobacteria represent a public health risk due to their cyanotoxins such as microcystins. Liquid chromatography techniques to separate and quantify microcystins invariably use acetonitrile as the organic component of the mobile phase. The price and availability of acetonitrile together with its elevated toxicity… Show more

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Cited by 4 publications
(4 citation statements)
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References 18 publications
(19 reference statements)
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“…The results showed the possibility of differentiation and quantification of the different samples of each curve. The responsible standards require values below 0.5 g L -1 , and the present method is applicable (Cassini et al, 2013;Souza and Junqueira, 2005), except only for lactic acid that showed a value above that specified by the standard.…”
Section: Precisionmentioning
confidence: 94%
“…The results showed the possibility of differentiation and quantification of the different samples of each curve. The responsible standards require values below 0.5 g L -1 , and the present method is applicable (Cassini et al, 2013;Souza and Junqueira, 2005), except only for lactic acid that showed a value above that specified by the standard.…”
Section: Precisionmentioning
confidence: 94%
“…23,28,57 However, this solvent is rapidly absorbed when in contact with the skin, lungs, and digestive system, spreading rapidly throughout the body, potentially causing serious deleterious effects in case of intoxication due to its degradation in cyanide, a strong inhibitor of the electron transport chain. 58,59 With regard to methanol, also a widely used solvent in liquid chromatography, this can be used as an alternative to toxic acetonitrile since it also presents favourable chromatographic properties, such as relatively low viscosity and UV cut-off wavelength of 205 nm. However, methanol can be metabolised by the toxic and cumulative formic acid and formaldehyde in humans after being readily absorbed by dermal exposure or vapour inhalation.…”
Section: Performance Of the Developed Method: Holistic Comparison With Reference Workmentioning
confidence: 99%
“…Comparando os valores de referência e os valores dos efeitos obtidos a partir das respostas das áreas dos picos (Tabela 9), percebe-se que as áreas dos picos não são influenciadas pela variação de nenhum parâmetro. Já com relação às respostas do TR, observa-se que todos os resultados foram menores do que o valor do critério s 2 , exceto o do parâmetro temperatura da coluna, conforme também observado por Silvino e Capelo-Neto (2014) e Cassini et al (2013). Portanto, o método apresentou sensibilidade à variação da temperatura da coluna em 3 °C.…”
Section: Robustezunclassified