Stability-indicating comparative methods using mekc and lc for determination of olmesartan medoxomil

Abstract

Recebido em 24/2/12; aceito em 25/7/12; publicado na web em 11/12/12 A stability-indicating method using MEKC was validated for the analysis of olmesartan medoxomil in tablets. Successful separation was achieved using a fused silica capillary (40 cm x 50 μm i.d.); background electrolyte consisted of a combination of 10 mmol L -1 borate buffer and 5 mmol L -1 anionic detergent sodium dodecyl sulfate (95:5; v/v) pH 6.5; hydrodynamic mode at 50 mBar for 5 s; 25 kV separation voltage at 25 °C; and column temperature 25 °C with detection at 257 nm. The proposed method, validated following ICH guidelines, was applied to the determination of this antihypertensive with good results compared with an LC method.

Sensitive Liquid Chromatographic Assay for Simultaneous Determination of Olmesartan and Its Prodrug Olmesartan Medoxomil in Rabbit Plasma

“…A literature survey revealed that several analytical methods were reported for the determination of olmesartan medoxomil in pharmaceutical dosage forms and in biological fluids including liquid chromatography tandem mass spectrometry (LC-MS-MS), capillary electrophoresis (CE), UV spectrophotometry, LC and high performance thin layer chromatography (HPTLC) [7][8][9][10][11][12] . Olmesartan medoxomil determination has been reported for single preparations or in combination with other antihypertensive drugs [13][14][15][16][17][18] .…”