Indirect spectrophotometric method for determination of captopril using Cr(VI) and diphenylcarbazide

Abstract

Recebido em 21/9/11; aceito em 6/4/12, publicado na web em 3/7/12 A spectrophotometric method for the indirect determination of captopril (CP) in pharmaceutical formulations is proposed. The proposed procedure is based on the oxidation of captopril by potassium dichromate and the determination excess oxidant on the basis of its reaction with diphenylcarbazide (DPC). Under the optimum conditions, a good linear relationship (r = 0.9997) was obtained in the range of 0.08-3.5 μg mL -1. The assay limits of detection and quantitation were 0.024 and 0.08 μg mL -1 , respectively. The results obtained for captopril determination in pharmaceuticals using the proposed method and those obtained with the US Pharmacopoeia method were in good agreement at the 95% confidence level.

Developing Metal Complexes for Captopril Quantification in Tablets Using Potentiometric and Conductometric Methods

“…18 It can be seen that CAP can be detected at 0.64 mg/mL (SD = 0.20, R = 0.9992 (n = 5)). The calculated correlation coefficients are quite similar to those obtained earlier using various approaches for determining CAP like chromatography, 3−6 fluorometry, 7−9 UV−visible spectroscopy, 10,11 chemiluminescence, 12 voltammetry, 13−17 potentiometry, 25−28 and conductometry 29−32 methods. Using the proposed methods, CAP was determined successfully over a concentration range from 0.83 to 13.04 mg/mL (Figure 5).…”

“…Captopril (CAP), also known chemically as [2S]-N-[3-mercapto-2-methylpropionyl)-L-proline, is a broadly utilized drug for the treatment of high blood pressure, diabetic nephropathy, congestive heart seizure, and the preservation of kidney damage. , In order to investigate the presence of CAP in pharmaceuticals, numerous analytical procedures have been postulated. CAP was determined using chromatography, − fluorometry, − UV–visible spectroscopy, , chemiluminescence, and voltammetric techniques. − Although these analytical strategies are highly sensitive and accurate, they are costly, time-consuming, and require complex procedures for sample preparation and analysis protocols.…”

“… 1 , 2 In order to investigate the presence of CAP in pharmaceuticals, numerous analytical procedures have been postulated. CAP was determined using chromatography, 3 − 6 fluorometry, 7 − 9 UV–visible spectroscopy, 10 , 11 chemiluminescence, 12 and voltammetric techniques. 13 − 17 Although these analytical strategies are highly sensitive and accurate, they are costly, time-consuming, and require complex procedures for sample preparation and analysis protocols.…”