Avaliação da porosidade de microcápsulas contendo proteína bioativa por porosimetria de mercúrio e adsorção de nitrogênio

Porte, Luciana Helena Maia; Leão, Maria Helena Miguez Rocha; Porte, Alexandre

doi:10.1590/s0100-40422011000900018

Cited by 9 publications

(7 citation statements)

References 20 publications

(35 reference statements)

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“…Results shown in Table 3 confirm the influence of particle size on the deposition of oxide. Fibres prepared with sifted in a 20 mesh sieve, showed a smaller content of zirconium on surface fibres, confirming the study of Bittencourt et al (2009) and Porte et al (2011).…”

Section: Fig 2 X-ray Diffraction Patterns For Palm Fibressupporting

confidence: 85%

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Chemical Modification of Palm Fibres Surface with Zirconium Oxychloride

2013

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Chemical modification of natural fibres has been carried out using different methods for such purposes as reinforcement in polymer matrices and heavy metals adsorption. In this work, palm fibres were modified by zirconium oxychloride in situ. The palm fibres that had been chemically modified were compared to those in nature using fibres that passed through 20 and 40 mesh screens to evaluate the influence of particle size on modification. Palm fibres were modified with ZrO 2 .nH 2 O nanoparticles through the use of zirconium oxychloride in an acidic medium in the presence of palm fibres using ammonium solution (1:3) as the precipitating agent. Scanning electron microscopy (SEM), X-ray diffraction (XRD), infrared spectrophotometry (FTIR), and atomic emission spectrometry with inductively coupled plasma (ICP-AES) were used to characterize the hybrid materials. Results indicated that the particle size of the palm fibres influenced in the modification, because the fibres with smaller particle size had a greater deposition of inorganic material. The ICP technique revealed an increase of 21% nanoparticles ZrO 2 .nH 2 O deposited on fibres (40 mesh) when compared to fibres (20 mesh). The diameter of nanoparticles ZrO 2 .nH 2 O deposited on fibres was about 50 to 220 nm, as observed by SEM.

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Section: Fig 2 X-ray Diffraction Patterns For Palm Fibressupporting

confidence: 85%

“…According to Bittencourt et al (2009), when reducing the particle size, both the surface area and the contact areas between adjacent fibers are increased, decreasing the material size. According to Porte et al (2011), small particles case agglomeration.…”

Section: Fig 2 X-ray Diffraction Patterns For Palm Fibresmentioning

confidence: 99%

Chemical Modification of Palm Fibres Surface with Zirconium Oxychloride

2013

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“…Besides this, the indication of the encapsulating capacity of a polymer is given by the degree of integrity and porosity of the particles formed. Although the particles produced here had some surface depressions or irregularities, we did not find the occurrence of microfissures and cracks on their surface, suggesting good capacity to encapsulate active ingredients [63].…”

Section: Scanning Electron Micrographymentioning

confidence: 54%

Development of Polycaprolactone/Poly(Vinyl Alcohol)/Clay Microparticles by Spray Drying

Monteiro¹,

Rodrigues²,

Miguez³

et al. 2016

MSA

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In this study, nanostructured microparticles was developed with polycaprolactone (PCL), poly(vinyl alcohol) (PVAL) and nanoparticles of the commercial sodium clay NT-25® by using the spray drying technique. The systems obtained were characterized by Nuclear Magnetic Resonance (NMR), Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectroscopy (FTIR), X-ray Diffraction (XRD), Dynamic Laser Light Scattering (DLS) and Differential Scanning Calorimetry (DSC). The NMR 13 C and FTIR techniques showed that both polymers were present in the microparticles and the DSC analysis revealed a small variation in the glass transition temperature of the PCL. The XRD and SEM analyses showed that the microparticles produced were amorphous and had a concave morphology. The NT-25 nanoload reduced the microparticles' size due to the multiple interactions formed in the hybrid nanocomposite material. Therefore, it was possible to develop microparticles by using biodegradable and biocompatible polymers, with different polarities, allowing the incorporation of hydrophilic and hydrophobic materials and enabling the inclusion of otherwise incompatible materials in the same system.

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“…In this sense, determinations of surface area and porosity are critical for pharmaceutical preformulation studies in formulation and development of new dosage forms. Therefore, the extract has a high porosity, with 2.3399 m²/g of surface area and 0.0064 cm³/g of pore volume, which confers good solubility by facilitating liquids penetration (Porte et al, 2011;Santos, 2013).…”

Section: Dry Extract Characterizationmentioning

confidence: 99%

Libidibia ferrea extract as a promising antidiabetic agent: characterization, pre-clinical analysis and development of pharmaceutical dosage forms / Extrato de Libidibia ferrea como um promissor agente antidiabético: caracterização, análise pré-clínica e desenvolvimento de formas de dosagem farmacêutica

Lima¹,

Melo²,

Sales³

et al. 2021

BJDV

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The present work aimed at developing pharmaceutical dosage forms based on the dry bark extract of Libidibia ferrea for the treatment of diabetes mellitus. The physicochemical characterization of the plant raw material, extractive solution and dry extract obtained by freeze drying were carried out. Effervescent granules, oral solution and tablets from the dry extract were developed and subjected to the recommended quality control tests. All materials presented standardized values after physical-chemical characterization. The presence of several secondary compounds was confirmed, and the content of the tannins was determined. The extract did not present acute toxicity in the in vivo experiment and provided an increase in glucose uptake in the in vitro study. The developed formulations complied with previously established values for quality control. The results show the safety and efficacy of the developed products, may being promising options in the treatment of diabetes mellitus.

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Avaliação da porosidade de microcápsulas contendo proteína bioativa por porosimetria de mercúrio e adsorção de nitrogênio

Cited by 9 publications

References 20 publications

Chemical Modification of Palm Fibres Surface with Zirconium Oxychloride

Chemical Modification of Palm Fibres Surface with Zirconium Oxychloride

Development of Polycaprolactone/Poly(Vinyl Alcohol)/Clay Microparticles by Spray Drying

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