2011
DOI: 10.1590/s0100-40422011000200024
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Abstract: Recebido em 9/3/10; aceito em 20/8/10; publicado na web em 30/11/10 PATHOPHYSIOLOGIC RELATIONSHIPS BETWEEN OXIDATIVE STRESS AND ATHEROSCLEROSIS. Oxidative stress is the result of an imbalance between oxidant and antioxidant species, with predominance of oxidative species with harmful action of reactive oxygen species (ROS) and reactive nitrogen species (RNS) on cells. Changes in the levels of nitric oxide (NO • ) can be the cause and/ or a result of various pathophysiological processes. The main objective of t… Show more

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Cited by 18 publications
(13 citation statements)
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References 41 publications
(57 reference statements)
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“…The FAs are the main source of energy for the heart, and L -carnitine transfers the FA across mitochondrial membranes to produce energy [1]. In the literature, it is well established that CABG surgery produces an increase up to 10% in the LVEF value, with improvement of the left ventricular systolic function [23,24].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The FAs are the main source of energy for the heart, and L -carnitine transfers the FA across mitochondrial membranes to produce energy [1]. In the literature, it is well established that CABG surgery produces an increase up to 10% in the LVEF value, with improvement of the left ventricular systolic function [23,24].…”
Section: Discussionmentioning
confidence: 99%
“…Ischemic heart disease is a leading cause of death in men and women over 30 years old [1]. It is the result of myocardial ischemia, often caused by the obstruction of blood flow in the coronary arteries by atheroma [2].…”
Section: Introductionmentioning
confidence: 99%
“…The guidelines for proper fatty acids consumption suggest consumption according to the total caloric value of the diet from lipids with 7% of calories from saturated fatty acids, 15% from monoun oxidation (27). Then, an inflammatory response oc curs, which ultimately results in endothelial dysfunc tion, platelet aggregation, formation of foam cells and thrombogenesis (28). This is the first step in athero sclerotic plaque formation, culminating in the emer gence of atherosclerosis.…”
Section: Discussionmentioning
confidence: 99%
“…Some authors refer to the peculiar ways of the metalloproteinases action in inflammation and blood vessel injuries, as, for example, the ability of MMP-12 in cleave fibrinogen 38 , the improved expression of MMP-2 and 9 provokes the development of hypertension, caused by hypertrophy of arterial wall with excessive deposition of collagen and elastin, as well as increases the oxidative stress 43 and vascular contraction along the vascular remodeling. This oxidative stress launches a sequence of events that are responsible for the endothelium damage, which start the atherosclerotic lesion in the vascular wall and induce the formation of oxidized-LDL (ox-LDL ) and promoting the development of the atherosclerotic lesion.…”
Section: Others Activities Of Metalloproteinasesmentioning
confidence: 99%