Flavonas, lignanas e terpeno de Piper umbellata (Piperaceae)

Baldoqui, Débora Cristina; Bolzani, Vanderlan da Silva; Furlan, Maysa; Kato, Massuo Jorge; Marques, Márcia Ortiz Mayo

doi:10.1590/s0100-40422009000500005

Cited by 23 publications

(18 citation statements)

References 35 publications

(45 reference statements)

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“…(Piperaceae) demonstrated the presence of several chemical constituents, such as β-stigmasterol, β-sitosterol, and campesterol (Perazzo et al, 2005;Pino et al, 2005;Baldoqui et al, 2009;Bagatela et al, 2013). Plants containing these bioactive molecules have previously demonstrated a significant anti-inflammatory activity (Navarro et al, 2001).…”

Section: Phytochemical Constituents Of P Umbellata Lmentioning

confidence: 99%

Investigation of the inhibitory effects from the Brazilian medicinal plant Pothomorphe umbellata L. (Piperaceae) on the molecular pathways of cyclooxygenase-2 and nuclear factor kappa B

Lopes¹,

Bagatela²,

Fonseca³

et al. 2016

J. Med. Plants Res.

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Presently, medicinal plants, such as Pothomorphe umbellata L. (Piperaceae), have been assessed as sources of potential therapeutic medicines. The inhibitory effects of the crude extract, fractions and 4-nerolidylcathecol, a phenolic compound which has been assigned significant activity in several beneficial properties performed by the plant, on the molecular pathways of cyclooxygenase-2 (COX-2) and nuclear factor kappa B (NF-κB) were evaluated. The in vitro inhibition of COX-2 was performed by enzyme-linked immunosorbent assay (ELISA). Methylene chloride fraction demonstrated the preeminent inhibition of COX-2. In order to estimate the inhibition of NF-κB, an adaptation of the luciferase plasmid assay was developed. 4-Nerolidylcathecol presented the best inhibition NF-κB activity. The results obtained from the in vitro assays were promising, mainly on the molecular pathway of NF-κB, once 4-nerolidylcathecol demonstrated a remarkable inhibition activity.

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Section: Phytochemical Constituents Of P Umbellata Lmentioning

confidence: 99%

Investigation of the inhibitory effects from the Brazilian medicinal plant Pothomorphe umbellata L. (Piperaceae) on the molecular pathways of cyclooxygenase-2 and nuclear factor kappa B

Lopes¹,

Bagatela²,

Fonseca³

et al. 2016

J. Med. Plants Res.

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“…Studies of Piper species have revealed the presence of several classes of secondary metabolites, 1 including alkaloids, amides, 2-6 chromenes, 7,8 neolignans, 9 lignans, terpenes, 10,11 benzoic acid derivatives 12,13 and kavalactones.…”

Section: Introductionmentioning

confidence: 99%

Kavalactones and Benzoic Acid Derivatives from Leaves of Piper fuligineum Kunth (Piperaceae)

Mazzeu¹,

Felippe²,

Cotinguiba³

et al. 2017

J. Braz. Chem. Soc.

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The known kavalactones (E)-4-methoxy-6-styryl-2H-pyran-2-one, 4-methoxy-6-(3-phenyloxiran-2-yl)-2H-pyran-2-one, 6-(1,2-dihydroxy-2-phenylethyl)-4-methoxy-2H-pyran-2-one, the three benzoic acid derivatives methyl-4-methoxy-3-(3'-methyl-2'-butenyl)benzoate and methyl 2,2-dimethyl-4-oxochroman-6-carboxylate, and a new methyl 4-methoxy-3-(3-methylbut-2-enoyl)benzoate were isolated from the ethanolic extract of Piper fuligineum. The structures of these compounds were determined by using a combination of spectroscopic methods, including 1D-and 2D-nuclear magnetic resonance spectroscopy and high-resolution mass spectrometry. This is the first report of the chemical study of P. fuligineum, and the methyl 4-methoxy-3-(3-methylbut-2-enoyl)benzoate is described as a new natural product.

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“…However, the active principles responsible for the observed antimicrobial properties are not known with certainty hence concerted efforts should be made to isolate and characterize the active principle responsible for the observed antibiotic effects. In this regard, Tabopda et al (2008) isolated and characterized four alkaloids from branches of P. umbellatum and showed they possessed α-glycosidase inhibition, antioxidant and antifungal activities while Baldoqui et al (2009) reported the isolation and characterization of nine compounds from leaves of P. umbellatum including one terpenoid, five flavones and two lignans. In this paper we report the isolation, purification and characterization of an antibiotic compound from the acidic metabolite of P. umbellatum seeds with a view to identify the phytochemical compound responsible for the observed antimicrobial and preservative properties of the plant.…”

Section: Introductionmentioning

confidence: 99%

Bioassay-Guided Isolation, Purification and Charaterization of Antimicrobial Compound From Acidic Metabolite of Piper umbellatum Seed Extract

Ejele¹,

Akalezi²,

Iwu³

et al. 2014

IJC

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The antimicrobial potential of ethanol extract of Piper umbellatum seeds and its acidic, basic and neutral metabolites were evaluated using the disc diffusion method. The results showed that the acidic and neutral metabolites exhibited greater antibiotic activities against the tested microorganisms; Coliform bacilli, Salmonella typhi and Staphylococcus aureus and gave inhibition zone diameters greater than 28 mm against both C. bacilli and S. aureus. These results were interpreted in terms of differences in phytochemical composition of these metabolites and indicated that an effective anti-Staphylococcal drug could be developed from P. umbellatum extract for chemotherapy of diseases caused by S. aureus, which is known all over the world to develop resistance to most potent antibiotic drugs. Chromatographic purification of the acidic metabolite gave five fractions whose antimicrobial potential against some pathogens was evaluated and compared with Amoxil (a positive standard antimicrobial drug). The results showed that all the chromatographic fractions possessed inhibitory activities against the tested microbes. Spectroscopic analysis of IR, 1 H-and 13 C-NMR data suggested that the active principle in acidic metabolite of P. umbellatum could be Naringin, a naturally occurring polyphenol and antibiotic drug.

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Flavonas, lignanas e terpeno de Piper umbellata (Piperaceae)

Cited by 23 publications

References 35 publications

Investigation of the inhibitory effects from the Brazilian medicinal plant Pothomorphe umbellata L. (Piperaceae) on the molecular pathways of cyclooxygenase-2 and nuclear factor kappa B

Investigation of the inhibitory effects from the Brazilian medicinal plant Pothomorphe umbellata L. (Piperaceae) on the molecular pathways of cyclooxygenase-2 and nuclear factor kappa B

Kavalactones and Benzoic Acid Derivatives from Leaves of Piper fuligineum Kunth (Piperaceae)

Bioassay-Guided Isolation, Purification and Charaterization of Antimicrobial Compound From Acidic Metabolite of Piper umbellatum Seed Extract

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