volume 31, issue 2, P290-295 2008
DOI: 10.1590/s0100-40422008000200019
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Abstract: Recebido em 13/2/07; aceito em 13/7/07; publicado na web em 19/12/07 PHYSICO-CHEMICAL CHARACTERIZATION OF INCLUSION COMPLEX BETWEEN HYDROXYMETHYLNITRO-FURAZONE AND HYDROXYPROPYL-β-CYCLODEXTRIN. Hydroxymethylnitrofurazone (NFOH) is a prodrug that is active against Trypanosoma cruzi. It however presents low solubility and high toxicity. Hydroxypropyl-β-cyclodextrin (HP-β-CD) can be used as a drug-delivery system for NFOH modifying its physico-chemical properties. The aim of this work is to characterize the incl…

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