Desreguladores endócrinos no meio ambiente: efeitos e conseqüências

Bila, Daniele Maia; Dezotti, Márcia

doi:10.1590/s0100-40422007000300027

Cited by 205 publications

(127 citation statements)

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“…4 This problem has been observed in many reservoirs of the Ceará, such as Gavião and Ayres de Souza dams, responsible for the water public supply of Fortaleza and Sobral cities, respectively, which shows evidence of the evolutionary framework of eutrophication, due to the discharge of these wastes without any treatment, alerting the population to a possible status of public calamity. 5 Many of these substances are of great scientific interest due to their ability to interfere with the endocrine system of humans and other animals, as well as their offspring, blocking, mimicking, stimulating and/or inhibiting the production of natural hormones.…”

Section: Introductionmentioning

confidence: 99%

“…5 Many of these substances are of great scientific interest due to their ability to interfere with the endocrine system of humans and other animals, as well as their offspring, blocking, mimicking, stimulating and/or inhibiting the production of natural hormones. 4,6,7 These natural or synthetic contaminants are known as endocrine disruptors (EDs) and have been one of the most relevant topics in environmental chemistry in terms of water quality. 2,4,6,7 Dexamethasone, 9-fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione, represented by DMZ (Figure 1), is an important catabolic steroid that has a 40-fold greater potency than natural glucocorticoids, such as cortisol and corticosterone, with strong anti-inflammatory and immunosuppressive action.…”

Section: Introductionmentioning

confidence: 99%

“…4,6,7 These natural or synthetic contaminants are known as endocrine disruptors (EDs) and have been one of the most relevant topics in environmental chemistry in terms of water quality. 2,4,6,7 Dexamethasone, 9-fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione, represented by DMZ (Figure 1), is an important catabolic steroid that has a 40-fold greater potency than natural glucocorticoids, such as cortisol and corticosterone, with strong anti-inflammatory and immunosuppressive action. 8 Despite its usefulness in the human and veterinary medicine, special care has been dedicated to this drug due to its characteristics as an endocrine disruptor.…”

Section: Introductionmentioning

confidence: 99%

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Direct electrochemical analysis of dexamethasone endocrine disruptor in raw natural waters

Oliveira

Ribeiro

Nascimento

et al. 2012

J. Braz. Chem. Soc.

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Este trabalho descreve uma metodologia eletroanalítica, utilizando voltametria adsortiva de onda quadrada, que foi aplicada com êxito na determinação direta de resíduos de dexametasona em águas naturais brutas utilizadas no abastecimento público do Estado do Ceará, Brasil. Os limites de detecção obtidos variaram entre 7,47 × 10 -9 e 1,80 × 10 -8 mol L -1 para as três matrizes de águas naturais brutas avaliadas. Os valores percentuais médios de recuperação (98,86% ± 0,72), repetibilidade (0,32% ± 0,05) e reprodutibilidade (0,91% ± 0,20) foram significativos, reafirmando a sensibilidade do procedimento. A energia dos orbitais LUMO e as cargas atômicas de Mülliken foram calculadas usando o funcional BLYP/DNP. Os resultados teóricos, aliados aos critérios de diagnóstico da voltametria de onda quadrada, indicam que o mecanismo redox da dexametasona está associado a processos de redução quase-reversível e irreversível dos grupos cetona localizados em C-20 e C-3, respectivamente. This paper describes an electroanalytical methodology using square-wave adsorptive voltammetry, which has been successfully applied for the direct determination of dexamethasone residues in raw natural waters used for the public supply of the Ceará State, Brazil. The obtained detection limits ranged from 7.47 × 10 -9 to 1.80 × 10 -8 mol L -1 for the three matrices of raw natural waters evaluated. High percentages of average recovery (98.86% ± 0.72), repeatability (0.32% ± 0.05) and reproducibility (0.91% ± 0.20) were obtained in these samples, reaffirming the sensitivity of the procedure. Energy of the LUMO orbitals and Mülliken's atomic charges were calculated using the functional BLYP/DNP. The theoretical results allied to the diagnostic criteria of the square-wave voltammetry indicate that the dexamethasone redox mechanism is associated to the quasi-reversible and irreversible reduction process of the ketone groups located at C-20 and C-3, respectively.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Direct electrochemical analysis of dexamethasone endocrine disruptor in raw natural waters

Oliveira

Ribeiro

Nascimento

et al. 2012

J. Braz. Chem. Soc.

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“…1,2 ED can block cellular receptor sites or increase the production and/or secretion of hormones, hence interfering in the reproductive systems of living organisms. [3][4][5] Many compounds are suspected of interfering with the endocrine system, 6 including natural and synthetic estrogens (lipidsoluble steroid hormones) such as 17a-ethynylestradiol, polycyclic aromatic hydrocarbons (compounds containing two or more conjugated aromatic rings, such as benzo(a) anthracene), polychlorinated biphenyls (highly toxic chlorinated compounds), pesticides (substances such as dichlorodiphenyltrichloroethane (DDT), used to repel or eliminate pathogenic insects), and plasticisers such as bisphenol A that are used in polymeric plastics. 7 ED are conveyed to aquatic systems by various natural or anthropogenic mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Characterization of the interactions between endocrine disruptors and aquatic humic substances from tropical rivers

Botero¹,

Oliveira²,

Cunha³

et al. 2011

J. Braz. Chem. Soc.

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Interações entre substâncias húmicas aquáticas (SHA), de rios tropicais, e dois interferentes endócrinos (IE) foram estudados utilizando sistema de ultrafiltração em fluxo tangencial equipado com membrana de celulose de 1 kDa com a finalidade de separar os IE livres da fração ligada as SHA. A quantificação de 17a-etinilestradiol e bisfenol A foi realizada utilizando cromatógrafo a gás acoplado a espectrômetro de massas (GC-MS). O tempo de equilíbrio entre as SHA e IE foi de aproximadamente 30 min, e as capacidades complexantes do 17a-etinilestradiol e bisfenol A foram em torno de 18,53 e 2,07 mg g -1 de carbono orgânico total (COT), respectivamente. A maior interação das SHA ocorreu para 17a-etinilestradiol, em relação ao bisfenol A, devido a presença de hidrogênio na estrutura do 17a-etinilestradiol, que podem interagir com os grupos oxigenados presentes nas SHA. Os resultados indicam que as SHA podem influenciar fortemente no transporte e reatividade dos interferentes endócrinos presentes em sistemas aquáticos.Interactions between two endocrine disruptors (ED) and aquatic humic substances (AHS) from tropical rivers were studied using an ultrafiltration system equipped with a 1 kDa cut-off cellulose membrane to separate free ED from the fraction bound in the AHS. Quantification of 17a-ethynylestradiol and bisphenol A was performed using gas chromatography-mass spectrometry (GC-MS). The times required for establishment of equilibrium between the AHS and the ED were ca. 30 min, and complexation capacities for 17a-ethynylestradiol and bisphenol A were 18.53 and 2.07 mg g -1 TOC, respectively. The greater interaction of AHS with 17a-ethynylestradiol, compared to bisphenol A, was due to the presence of hydrogen in the structure of 17a-ethynylestradiol, which could interact with ionized oxygenated groups of the AHS. The results indicate that AHS can strongly influence the transport and reactivity of endocrine disruptors in aquatic systems.Keywords: water, pollution, endocrine disruptors, aquatic humic substances, complexation capacity IntroductionPopulation increase, the development of new products, and intensified use of terrestrial and aquatic resources in industry and agriculture have resulted in the introduction into the environment of new compounds that may cause toxicity in humans and animals. Endocrine disruptors (ED) are often found in surface waters and effluents, where they can pose health risks even at low concentrations. In 1996, the European Commission defined this class of compounds as "exogenous substances that cause adverse health effects in the intact organism, or in its descendents, resulting in alterations of endocrine functions". 1,2 ED can block cellular receptor sites or increase the production and/or secretion of hormones, hence interfering in the reproductive systems of living organisms. 3-5 Many Characterization of the Interactions between Endocrine Disruptors and Aquatic Humic Substances J. Braz. Chem. Soc. 1104 compounds are suspected of interfering with the endocrine system, 6 inclu...

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“…1,[7][8][9][10] Os retardantes de chamas bromados são, de maneira geral, persistentes, lipofílicos e apresentam elevado potencial para bioacumulação, tendo sua ocorrência na biota associada a efeitos deletérios, além de produzirem grande quantidade de fumaça e gases tóxicos nos incêndios. 11,12 A presença desses compostos já foi relatada em todos os compartimentos ambientais e em diferentes regiões do globo, incluindo regiões remotas onde não há histórico do seu uso e/ou produção (por exemplo, as regiões polares). [13][14][15] Alguns desses compostos (PBBs, Penta-BDE, Octa-BDE e Deca-BDE) já tiveram a sua produção e comercialização restringida ou proibida em alguns países (ex.…”

Section: Introductionunclassified