2005
DOI: 10.1590/s0100-40422005000500028
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Abstract: Recebido em 17/8/04; aceito em 5/11/04; publicado na web em 13/4/05 RIBOFLAVIN: A MULTIFUNCTIONAL VITAMIN. Riboflavin, a component of the B 2 vitaminic complex, plays important roles in biochemistry, especially in redox reactions, due to the ability to participate in both one-and two-electron transfers as well as acting as a photosensitizer. Accordingly, low intakes of this vitamin have been associated with different diseases, including cancer and cardiovascular diseases. Riboflavin is thought to contribute to… Show more

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Cited by 20 publications
(20 citation statements)
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“…A fotoquímica da riboflavina é bem conhecida, bem como suas interações com ácidos nucléicos 60 . Embora esse tipo de estudo esteja apenas em sua fase inicial, sabe-se que riboflavina é ativa em cada um dos principais componentes do sangue sem dano significante a essas estruturas, inclusive no uso em RBC 14 .…”
Section: Riboflavinaunclassified
“…A fotoquímica da riboflavina é bem conhecida, bem como suas interações com ácidos nucléicos 60 . Embora esse tipo de estudo esteja apenas em sua fase inicial, sabe-se que riboflavina é ativa em cada um dos principais componentes do sangue sem dano significante a essas estruturas, inclusive no uso em RBC 14 .…”
Section: Riboflavinaunclassified
“…1), 7,8-dimethyl-10-ribityl-isoalloxazine, one of the components of the B 2 vitamin complex, is an efficient photosensitizer that has been used in several photodynamic therapy studies [2]. Riboflavin is particularly sensitive to UV and visible light and acts via the generation of singlet oxygen (type II mechanism) or via radical species (type I mechanism), including reactive oxygen species such as the superoxide ion, hydroxyl radical and hydrogen peroxide [3]. Although the reduction potential of riboflavin is − 0.3 V at pH 7.0, the redox potential of the excited triplet flavin can be shifted to 1.7 V [4] which is higher than the redox potential of important biomolecules such as amino acids, proteins, lipids and nucleic acids which can undergo photodegradation in the presence of riboflavin.…”
Section: Introductionmentioning
confidence: 99%
“…21,22 Indeed, yeast extract is largely used as source of vitamins in culture biomedia to boost the culture conditions and enhance microorganism activity. 23 Riboflavin is a precursor of important coenzymes (e.g., FAD, FMN) that participate in the cellular electron transport chain and is the source of many flavins that act catalyze important cellular reactions such as those involving DNA repair. 24 Because the azo dye was also significantly removed in the absence of anaerobic microorganisms (D4), the enhancement of cell growth by the addition of yeast extract cannot solely explain the greater color removal.…”
Section: Resultsmentioning
confidence: 99%