Avaliação e seguimento de pacientes adultos com síndrome do intestino curto pelo exame contrastado de trânsito intestinal

Chagas-Neto, Francisco Abaeté das; Barreto, André Rodrigues Façanha; Muglia, Valdair Francisco; Elías, Jorge; Bellucci, Ângela Delete; Marchini, Júlio Sérgio; Cunha, Selma Freire de Carvalho da

doi:10.1590/s0100-39842011000300013

Cited by 3 publications

(1 citation statement)

References 8 publications

(7 reference statements)

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“…In animals infected by T. cruzi and treated with homeopathic medicines, the increase of the colon length (Massini, 2013) and the preservation of gut neural population (Brustolin, 2014) were seen as attempts of the organism to balance the damage caused by the parasite in the intestine. Such anatomic and functional adaptability reveals the pursuit of the body to retake the digestive and absorptive functions (Hwang et al, 2002;das Chagas et al, 2011) and might explain the mass gain despite the low feed intake.…”

Section: Parasitological Parametersmentioning

confidence: 99%

The Association of Ponderal Benznidazole with its Ultra-high Diluted Formula Reduces the Toxic Effects and Allows Increasing of Dose in Dose-dependent Protocol in Mice Infected with Trypanosoma cruzi

Aleixo¹,

Benvenutti

Lera³

et al. 2021

Int J High Dilution Res

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Although several diseases are treated by toxic drugs, their side effects may hamper adherence to the therapy. The aim of this study is to evaluate the effect of the association of ponderal benznidazole (BZ) with its ultra-high diluted (UHD) formula on clinical and parasitological parameters of mice infected by Trypanosoma cruzi (T. cruzi). 24 non-isogenic Swiss mice were divided into groups: CI â€“ infected animals treated with 7% alcohol; BZp â€“ infected animals treated with BZ (500 mg/ kg) from the beginning of infection; BZp+d â€“ infected animals treated with ponderal BZ and with UHD BZ, which started to be administered four days after the beginning of treatment with ponderal BZ; CNI - group of non-treated and non-infected animals. The UHD medicine was prepared according to Phamacopoeia until 30x. The different treatment schedules were statistically compared through parasitological and clinical parameters. The group BZp+d displayed more favorable clinical evolution than the group BZp, with improvement of mass gain, feed conversion and water intake, presenting data approximated to CNI group. The significant increase of the body temperature of BZp+d group indicates an activation of the immune system which was not observed in the other groups. Moreover, the anti-parasitic effect of the ponderal drug was maintained in all parasitological parameters of this group. By reducing the side effects and maintaining the action of the ponderal drug, the combination of toxic drugs with their UHD formula could be considered a way of improving efficacy of the treatment.

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Section: Parasitological Parametersmentioning

confidence: 99%

The Association of Ponderal Benznidazole with its Ultra-high Diluted Formula Reduces the Toxic Effects and Allows Increasing of Dose in Dose-dependent Protocol in Mice Infected with Trypanosoma cruzi

Aleixo¹,

Benvenutti

Lera³

et al. 2021

Int J High Dilution Res

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Bioelectrical impedance vector analysis as a useful predictor of nutritional status in patients with short bowel syndrome

et al. 2017

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Energy intake in short bowel syndrome: assessment by 24-h dietary recalls compared with the doubly labelled water method

et al. 2017

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Short bowel syndrome (SBS) represents a serious intestinal absorption disorder, and patients may be prone to severe malnutrition. Dietetic therapy is critically important both for immediate prognosis and successful long-term rehabilitation. To maintain energy balance, an accurate assessment of energy intake is required. Our objective was to compare energy intake (EI) assessed by 24-h dietary recalls (EIrecall), a standard clinical assessment, with the total energy expenditure measured by the doubly labelled water (TEEdlw) method in SBS patients and matched controls. A total of twenty-two participants (eleven each in the SBS and control groups (CG), six female and five male) were evaluated; CG were matched to SBS patients on the basis of age, BMI and sex. TEE was measured by DLW and compared with EI determined by four 24-h dietary recalls using the USDA Automated Multiple-Pass Method. Bland-Altman plots and paired Student's t test were used to compare EIrecall with TEEdlw (P<0·05). Participants' mean age was 53 (sd 8) years. TEEdlw (7·85 (SD 1·16) MJ/d, 0·14 (SD 0·02) MJ/kg per d) was significantly lower (P=0·014) compared with EIrecall (11·07 (SD 3·45) MJ/d, 0·21 (SD 0·08) MJ/kg per d) in the SBS group. On the other hand, in the CG group TEEdlw (10·02 (SD 1·86) MJ/d, 0·18 (SD 0·03) MJ/kg per d) was significantly higher (P=0·001) compared with EIrecall (7·19 (SD 1·68) MJ/d, 0·13 (SD 0·03) MJ/kg per d). In SBS patients, reported EI is higher than DLW-measured EI. Therefore, providing or prescribing energetic intake based on EIrecall without accounting for potential malabsorption-related losses can compromise the energy needs in SBS patients and affect nutritional status in the long term.

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Avaliação e seguimento de pacientes adultos com síndrome do intestino curto pelo exame contrastado de trânsito intestinal

Cited by 3 publications

References 8 publications

The Association of Ponderal Benznidazole with its Ultra-high Diluted Formula Reduces the Toxic Effects and Allows Increasing of Dose in Dose-dependent Protocol in Mice Infected with Trypanosoma cruzi

The Association of Ponderal Benznidazole with its Ultra-high Diluted Formula Reduces the Toxic Effects and Allows Increasing of Dose in Dose-dependent Protocol in Mice Infected with Trypanosoma cruzi

Bioelectrical impedance vector analysis as a useful predictor of nutritional status in patients with short bowel syndrome

Energy intake in short bowel syndrome: assessment by 24-h dietary recalls compared with the doubly labelled water method

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