2015
DOI: 10.1590/s0080-623420150000200006
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Abstract: Usage of Calendula officinalis in the prevention and treatment of radiodermatitis: a randomized double-blind controlled clinical trial ABSTRACT Objective:To evaluate the efficacy of Calendula officinalis in relation to Essential Fatty Acids for the prevention and treatment of radiodermatitis. Method: This is a randomized double-blind controlled clinical trial with 51 patients with head and neck cancer in radiotherapy treatment divided into two groups: control (27) and experimental (24). Results: There is stat… Show more

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Cited by 41 publications
(41 citation statements)
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“…In the 20 th week there was a predominance of grade one radiodermatitis in both groups (EFA-70% and Calendula-66%), and grade two was present in 7.41% of the EFA group and in 8.33% of the Calendula group. 18 In the 25 th week, the highest incidence of grade 1 radiodermatitis remained in both groups (65.22% and 63.44%), followed by grade two in the EFA group (34.78%) and grade two and three in the Calendula group (13.64% each). At the end of the research the authors concluded that Calendula was more effective in preventing the development of radiodermatitis.…”
Section: Discussionmentioning
confidence: 85%
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“…In the 20 th week there was a predominance of grade one radiodermatitis in both groups (EFA-70% and Calendula-66%), and grade two was present in 7.41% of the EFA group and in 8.33% of the Calendula group. 18 In the 25 th week, the highest incidence of grade 1 radiodermatitis remained in both groups (65.22% and 63.44%), followed by grade two in the EFA group (34.78%) and grade two and three in the Calendula group (13.64% each). At the end of the research the authors concluded that Calendula was more effective in preventing the development of radiodermatitis.…”
Section: Discussionmentioning
confidence: 85%
“…The indexes of radiodermatitis identified can be compared with the results of a study that evaluated the effectiveness of Calendula officinalis in relation to Essential Fatty Acids (EFAs) for the prevention and treatment of radiodermatitis in head and neck cancer patients, in which the occurrence of radiodermatitis and its grades were analyzed. 18 In this clinical trial that included 51 patients who started radiotherapy treatment, it was shown that radiodermatitis developed from the 10 th session of radiotherapy, predominantly grade one (EFA-11%, Calendula-8%). In the 15 th session most did not present radiodermatitis, but 40% of the EFA group had grade one.…”
Section: Discussionmentioning
confidence: 96%
“…The relation of aging and skin alterations can be explained as the elderly go through a decrease in the production of collagen and fibroblasts, thereby hindering the healing of the skin lesions. 23,24 Different agents have been indicated for the prevention and treatment of skin lesions induced by radiation; 8,14 there is, however, still no robust scientific evidence that points to one specific intervention. 25 Thus, radiodermatitis remains an adverse effect of the oncological treatment of high incidence, 8 which requires further studies for its understanding and the establishment of strategies for tis prevention and treatment.…”
Section: Discussionmentioning
confidence: 99%
“…23,24 Different agents have been indicated for the prevention and treatment of skin lesions induced by radiation; 8,14 there is, however, still no robust scientific evidence that points to one specific intervention. 25 Thus, radiodermatitis remains an adverse effect of the oncological treatment of high incidence, 8 which requires further studies for its understanding and the establishment of strategies for tis prevention and treatment. 25 In addition to the known relationship between smoking and the incidence of different types of cancer, this study demonstrates the pernicious role of this habit also in the occurrence of radiodermatitis, a major adverse effect of antineoplastic therapy that impacts on patient's quality of life.…”
Section: Discussionmentioning
confidence: 99%
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