A morphologically distinct Phlebotomus argentipes population from active cutaneous leishmaniasis foci in central Sri Lanka

Ranasinghe, Shalindra; Maingón, R.; Bray, Daniel P.; Ward, R. D.; Udagedara, Chandani; Dissanayake, Manel; Jayasuriya, V; Silva, B. G. D. N. K. De

doi:10.1590/s0074-02762012000300016

Cited by 9 publications

(7 citation statements)

References 22 publications

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“…Three morphospecies were distinguished based on the length ratio of sensilla chaetica (SC2) on antennal flagellomere 2 (AF2) and male genitalia characters as described by Ilango (2000 and2010). All three morphospecies have been reported previously in Sri Lanka (Surendran et al, 2005;Gajapathy et al, 2011;Ranasinghe et al, 2012).…”

Section: Resultsmentioning

confidence: 99%

Genetic diversity of <em>Phlebotomus (Euphlebotomus) argentipes</em> species complex in Sri Lanka

et al. 2022

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Section: Resultsmentioning

confidence: 99%

Genetic diversity of <em>Phlebotomus (Euphlebotomus) argentipes</em> species complex in Sri Lanka

et al. 2022

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“…Furthermore, a new sibling population of the P. argentipes s.l. species complex in central Sri Lanka was identified [48]. Due to this complex species diversity, their evolutionary differences, relative vector capacities, and their disease transmission potentials should be investigated.…”

Section: Vectormentioning

confidence: 99%

A Comprehensive Review of Cutaneous Leishmaniasis in Sri Lanka and Identification of Existing Knowledge Gaps

Amarasinghe

Wickramasinghe

2020

Acta Parasit.

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Purpose Sri Lanka is endemic to cutaneous leishmaniasis and reported as the latest focus of leishmaniasis in the Asian subcontinent. Annually, the number of leishmaniasis cases is increasing; therefore, more efficient diagnostic tools, treatment methods and effective prevention measures are indispensable. For this reason, many studies were conducted regarding leishmaniasis infections in Sri Lanka; however, some areas need more attention. Thus, in this review, we comprehensively discussed the studies on leishmaniasis carried out in Sri Lanka. Methods Published articles on leishmaniasis in Sri Lanka were searched on PubMed, Google Scholar and ResearchGate databases. Inclusion criteria for the articles were based on keyword searches including 'Leishmaniasis in Sri Lanka', 'Leishmaniasis vector in Sri Lanka', 'Sandfly species in Sri Lanka', 'Leishmaniasis epidemiology in Sri Lanka' which are publicly accessible as of 15th July 2019. Results In this study, we evaluated and summarized the leishmaniasis reports in Sri Lanka and mainly focused on clinical presentation of leishmaniasis infection, genetic characteristics of Leishmania donovani Sri Lankan strain, geographical distribution and associated environmental factors, immunological aspects of the infection, vector, reservoir host, risk factors, diagnosis and treatment, and prevention and control. Furthermore, we identified the areas where further research is needed to fill the essential knowledge gaps. Conclusions Leishmaniasis has become a critically important parasitic infection in Sri Lanka, whereas the significant clinical form is cutaneous leishmaniasis. Prevalence of the leishmaniasis infections is reported from all the districts of the country. Therefore, more studies are essential to be carried out to fill the existing knowledge gaps emphasized in this review.

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“…Therefore, scientists suspected that P. argentipes is the vector of leishmaniasis in Sri Lanka. Interestingly, in 2009 studies revealed that all three members of Phlebotomus complex including, P. glaucus, P. argentipes , and P. annandalei are prevalent in Sri Lanka [ 75 ]. Molecular studies provide evidence for the presence of Leishmania DNA in blood fed and unfed female sand flies confirming the possibility of P. argentipes to act as vectors of leishmaniasis [ 76 ].…”

Section: Presence Of Vectors and Vector Control Approachesmentioning

confidence: 99%

Potential Challenges of Controlling Leishmaniasis in Sri Lanka at a Disease Outbreak

Wijerathna

Gunathilaka

Gunawardana

et al. 2017

BioMed Research International

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The present works reviewed the existing information on leishmaniasis in Sri Lanka and in other countries, focusing on challenges of controlling leishmaniasis in the country, in an outbreak. Evidence from recent studies suggests that there is a possibility of a leishmaniasis outbreak in Sri Lanka in the near future. Difficulty of early diagnosis due to lack of awareness and unavailability or inadequacy of sensitive tests are two of the main challenges for effective case management. Furthermore, the absence of a proper drug for treatment and lack of knowledge about vector biology, distribution, taxonomy and bionomics, and reservoir hosts make the problem serious. The evident potential for visceralization in the cutaneous variant of L. donovani in Sri Lanka may also complicate the issue. Lack of knowledge among local communities also reduces the effectiveness of vector and reservoir host control programs. Immediate actions need to be taken in order to increase scientific knowledge about the disease and a higher effectiveness of the patient management and control programs must be achieved through increased awareness about the disease among general public and active participation of local community in control activities.

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A morphologically distinct Phlebotomus argentipes population from active cutaneous leishmaniasis foci in central Sri Lanka

Abstract: Although the reported aetiological agent of cutaneous leishmaniasis (CL) in Sri Lanka is

Cited by 9 publications

References 22 publications

Genetic diversity of <em>Phlebotomus (Euphlebotomus) argentipes</em> species complex in Sri Lanka

Genetic diversity of <em>Phlebotomus (Euphlebotomus) argentipes</em> species complex in Sri Lanka

A Comprehensive Review of Cutaneous Leishmaniasis in Sri Lanka and Identification of Existing Knowledge Gaps

Potential Challenges of Controlling Leishmaniasis in Sri Lanka at a Disease Outbreak

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