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Cited by 13 publications
(8 citation statements)
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“…In this sense, as we mentioned, a previous study demonstrated that tamoxifen exerts a strong protective effect against experimental cysticercosis in mice by two main mechanisms: induction of the IL-2 expression, and by having direct detrimental effects upon Taenia crassiceps viability and reproduction [16]. It has been also reported that tamoxifen is able to directly diminish viability of all life cycle stages of Trypanosma cruzi at micromolar concentrations [13]. In a similar way, Leishmania braziliensis and L. chagasi intracellular amastigotes considerably decrease their viability in response to the in vitro treatment with tamoxifen [11].…”
Section: Discussionmentioning
confidence: 89%
See 1 more Smart Citation
“…In this sense, as we mentioned, a previous study demonstrated that tamoxifen exerts a strong protective effect against experimental cysticercosis in mice by two main mechanisms: induction of the IL-2 expression, and by having direct detrimental effects upon Taenia crassiceps viability and reproduction [16]. It has been also reported that tamoxifen is able to directly diminish viability of all life cycle stages of Trypanosma cruzi at micromolar concentrations [13]. In a similar way, Leishmania braziliensis and L. chagasi intracellular amastigotes considerably decrease their viability in response to the in vitro treatment with tamoxifen [11].…”
Section: Discussionmentioning
confidence: 89%
“…Interestingly, the use of this antiestrogenic drug has also proved to be effective against several protozoan parasites, including Leishmania major , L. braziliensis , L. chagasi , L. amazonensis , and Trypanosoma cruzi [1013]. Nevertheless, the tamoxifen effect upon helminth cestode parasites has been exclusively studied for the case of Taenia crassiceps , the causal agent of experimental murine cysticercosis [14].…”
Section: Introductionmentioning
confidence: 99%
“…TAM and its bioactive metabolites, 4-hydroxytamoxifen (4-OH-TAM) and N-desmethyl tamoxifen (ND-TAM), inhibit proliferation and induce apoptosis in several types of ER-positive and ER-negative breast cancer cells, rat mammary tumors, and other cancer types (7,8). Interestingly, this antiestrogenic drug has also proved to be effective against several protozoan parasites, including Leishmania major, Leishmania braziliensis, Leishmania chagasi, Leishmania amazonensis, and Trypanosoma cruzi (9)(10)(11). Furthermore, the effect of TAM on cestode parasites has been studied in Taenia crassiceps and Taenia solium (12,13).…”
mentioning
confidence: 99%
“…Tamoxifen is a competitive antagonist of the estrogen receptor that has been widely and globally used for treating breast cancer in premenopausal women and gynaecomastia in men receiving hormonal therapy for prostatic carcinoma (Rivera-Guevara and Camacho, 2011;Kennel et al, 2003 andMati andChen, 2003). Interestingly, the use of this antiestrogenic drug has also proved to be effective against several protozoan parasites, including Leishmania major, L. braziliensis, L. chagasi, L. amazonensis, Trypanosoma cruzi (Eissa et al, 2011;Miguel et al, 2008;Miguel et al, 2009;Miguel et al, 2010) and Taenia crassiceps (Larralde et al, 1989). With the exception of its action on uterus of guinea pigs (Pasqualini et al, 1986), not much has been documented on tamoxifen's action on organs of guinea pigs.…”
Section: Discussionmentioning
confidence: 99%