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Cited by 31 publications
(30 citation statements)
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“…(20) The flavonoids could be an important component in activating innate and adaptive immune cells as reported by Yuan et al (42) Phenolic compounds, such as cinnamic acid had been demonstrated to be effective in stimulating cytokine IL-1β production in murine macrophages. (46) A study conducted by Fischer et al (47) showed that the polyphenol compounds extracted from Brazilian green propolis could promote specific antibody secretion in mice. Artepillin-C, a low-molecular-weight phenolic compound, was effective in T helper cells expansion and activation, as well as macrophage activation as demonstrated previously by Cheung et al and Kimoto et al (31,48) Therefore, we consider a possibility that artepillin-C may be one of the most important ingredients in Brazilian green propolis in activating macrophage phagocytosis.…”
Section: Discussionmentioning
confidence: 99%
“…(20) The flavonoids could be an important component in activating innate and adaptive immune cells as reported by Yuan et al (42) Phenolic compounds, such as cinnamic acid had been demonstrated to be effective in stimulating cytokine IL-1β production in murine macrophages. (46) A study conducted by Fischer et al (47) showed that the polyphenol compounds extracted from Brazilian green propolis could promote specific antibody secretion in mice. Artepillin-C, a low-molecular-weight phenolic compound, was effective in T helper cells expansion and activation, as well as macrophage activation as demonstrated previously by Cheung et al and Kimoto et al (31,48) Therefore, we consider a possibility that artepillin-C may be one of the most important ingredients in Brazilian green propolis in activating macrophage phagocytosis.…”
Section: Discussionmentioning
confidence: 99%
“…The Brazilian green propolis is particularly rich in artepillin C (3,5-diprenyl-4-hydroxycinnamic acid), a phenolic compound with immunomodulatory and antiinflammatory properties that could be useful for treatment of udder infections (Paulino et al 2008;Messerli et al 2009;Fischer et al 2010).…”
Section: Introductionmentioning
confidence: 99%
“…This diversity of the propolis in Brazil is reflected on its several therapeutic properties such as antimicrobial, antiinflammatory, immunomodulatory, and anticancer activities (FISCHER et al, 2010;SILVA et al, 2012;MARCUCCI, 1996;BANKOVA, 2011). According to the results…”
Section: Discussionmentioning
confidence: 99%
“…Currently, the investigation of the chemical characteristics of propolis includes the use diverse methods and technologies, which have been applied mainly for determination of its chemical components, such as flavonoids, phenolics and antioxidant activity (CABRAL et al, 2009;ALENCAR et al;2007;LUO et al, 2011;MARÓSTICA JUNIOR et al, 2008;ALVES;KUBOTA, 2013;FISCHER et al, 2010;OLDONI et al, 2011;SILVA et al, 2012;NUNES et al, 2009;COTTICA et al, 2011).…”
Section: Introductionmentioning
confidence: 99%