2010
DOI: 10.1590/s0074-02762010000700001
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: The sequencing of the complete genome of Anaplasma marginale has enabled the identification of several genes that encode membrane proteins, thereby increasing the chances of identifying candidate immunogens. Little is known regarding the genetic variability of genes that encode membrane proteins in A. marginale isolates. The aim of the present study was to determine the degree of conservation of the predicted amino acid sequences of OMP1, OMP4, OMP5, OMP7, OMP8, OMP10, OMP14, OMP15, SODb, OPAG1, OPAG3, VirB3, … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

0
5
0

Year Published

2011
2011
2020
2020

Publication Types

Select...
6

Relationship

0
6

Authors

Journals

citations
Cited by 8 publications
(5 citation statements)
references
References 27 publications
0
5
0
Order By: Relevance
“…This would resolve whether there is a continuum of strain diversity among marginale strains eventually reaching that of the single currently sequenced centrale strain, originally isolated by Theiler in South Africa. A recent study [47] comparing membrane proteins from a Brazilian strain of A. marginale with Florida and St. Maries determined amino acid sequence identities of 92–100% for all OMPs investigated except OMP7, compared to 40–70% identities with the A. marginale subspecies centrale orthologs. This suggests that the diversity observed here among U.S. strains of A. marginale may at least be representative of marginale strains in North and South America.…”
Section: Discussionmentioning
confidence: 99%
“…This would resolve whether there is a continuum of strain diversity among marginale strains eventually reaching that of the single currently sequenced centrale strain, originally isolated by Theiler in South Africa. A recent study [47] comparing membrane proteins from a Brazilian strain of A. marginale with Florida and St. Maries determined amino acid sequence identities of 92–100% for all OMPs investigated except OMP7, compared to 40–70% identities with the A. marginale subspecies centrale orthologs. This suggests that the diversity observed here among U.S. strains of A. marginale may at least be representative of marginale strains in North and South America.…”
Section: Discussionmentioning
confidence: 99%
“…Nevertheless, it may play additional roles. It has recently been demonstrated that EF-Tu is released/secreted from bacterial cells and that it can modulate pathogen-host interactions (19)(20)(21)(22)(23)(24). However, the pathways by which EF-Tu protein might interfere with immune regulation in the host cell remain unknown.…”
Section: Discussionmentioning
confidence: 99%
“…Genome sequencing and proteomic analysis on A. marginale membrane proteins have identified a variety of other surface antigens (AGNES et al, 2011, DARK et al, 2011, including in Brazilian isolates (VIDOTTO et al, 2008;GUEDES JUNIOR et al, 2010). Nonetheless, although all these studies were conducted using A. marginale from infected cattle blood, no information on the influence of in vitro cultivation in tick cells on these proteins has been produced.…”
Section: Discussionmentioning
confidence: 99%