Expression of bacterial virulence factors and cytokines during in vitro macrophage infection by enteroinvasive Escherichia coli and Shigella flexneri: a comparative study

Bando, Sílvia Yumi; Moreno, Ana Carolina Ramos; Albuquerque, José Antônio Tavares de; Amhaz, Juliana Mota Khalil; Moreira-Filho, Carlos Alberto; Martinez, Marina Baquerizo

doi:10.1590/s0074-02762010000600009

Cited by 22 publications

(30 citation statements)

References 30 publications

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“…Consistent with our data, cytokine levels were found to be significantly lower in response to S. flexneri LPS/ lipid than to E. coli LPS/lipid (Rallabhandi et al 2008). Recently, Bando et al (2010) demonstrated that murine macrophages infected with EIEC or S. flexneri produce IL-10 and TNF-α, although there is no difference between the levels of cytokines released in response to these two species.…”

supporting

confidence: 91%

“…However, the disease induced by EIEC is generally less severe than that induced by Shigella spp (Dupont et al 1971, 1989. This difference in severity may be associated with a lower level of expression of virulence factors by EIEC in the presence of various host cells, such as macrophages and intestinal epithelial cells (Gibotti et al 2004, Moreno et al 2009, Bando et al 2010.…”

mentioning

confidence: 99%

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Recognition of enteroinvasive Escherichia coli and Shigella flexneri by dendritic cells: distinct dendritic cell activation states

Moreno

Ferreira

et al. 2012

Mem. Inst. Oswaldo Cruz

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supporting

confidence: 91%

mentioning

confidence: 99%

Recognition of enteroinvasive Escherichia coli and Shigella flexneri by dendritic cells: distinct dendritic cell activation states

Moreno

Ferreira

et al. 2012

Mem. Inst. Oswaldo Cruz

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“…In general, EIEC and Shigella employ the same strategies to invade host cells. Nevertheless, EIEC exhibits reduced virulence compared to that of Shigella, including reduced expression of virulence genes, less efficient macrophage killing, reduced cell-to-cell spread, and decreased induction of a proinflammatory host response (522,523), which correlates with the less severe disease induced by EIEC.…”

Section: Pathogenesismentioning

confidence: 99%

Recent Advances in Understanding Enteric Pathogenic Escherichia coli

et al. 2013

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SUMMARY Although Escherichia coli can be an innocuous resident of the gastrointestinal tract, it also has the pathogenic capacity to cause significant diarrheal and extraintestinal diseases. Pathogenic variants of E. coli (pathovars or pathotypes) cause much morbidity and mortality worldwide. Consequently, pathogenic E. coli is widely studied in humans, animals, food, and the environment. While there are many common features that these pathotypes employ to colonize the intestinal mucosa and cause disease, the course, onset, and complications vary significantly. Outbreaks are common in developed and developing countries, and they sometimes have fatal consequences. Many of these pathotypes are a major public health concern as they have low infectious doses and are transmitted through ubiquitous mediums, including food and water. The seriousness of pathogenic E. coli is exemplified by dedicated national and international surveillance programs that monitor and track outbreaks; unfortunately, this surveillance is often lacking in developing countries. While not all pathotypes carry the same public health profile, they all carry an enormous potential to cause disease and continue to present challenges to human health. This comprehensive review highlights recent advances in our understanding of the intestinal pathotypes of E. coli .

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“…EIEC are strains that possess some of the biochemical characteristics of E. coli and have the ability to cause dysentery using the same method of invasion as Shigella, however, the disease induced by EIEC is generally less severe [125]. This difference in severity may be associated with a lower level of expression of virulence factors by EIEC in the presence of various host cells, such as macrophages and IECs [126]. EIEC causes an invasive inflammatory colitis, and occasionally dysentery, but in most cases EIEC elicits watery diarrhea that is indistinguishable from that caused by other E. coli pathogens [26,127].…”

Section: E Coli Invading: Eiecmentioning

confidence: 99%

Role of Virulence Factors on Host Inflammatory Response Induced by Diarrheagenic Escherichia Coli pathotypes

Sanchez-Villamil

Navarro-Garcı́a

2015

Future Microbiol.

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Pathogens are able to breach the intestinal barrier, and different bacterial species can display different abilities to colonize hosts and induce inflammation. Inflammatory response studies induced by enteropathogens as Escherichia coli are interesting since it has acquired diverse genetic mobile elements, leading to different E. coli pathotypes. Diarrheagenic E. coli secrete toxins, effectors and virulence factors that exploit the host cell functions to facilitate the bacterial colonization. Many bacterial proteins are delivered to the host cell for subverting the inflammatory response. Hereby, we have highlighted the specific processes used by E. coli pathotypes, by that subvert the inflammatory pathways. These mechanisms include an arrangement of pro- and anti-inflammatory responses to favor the appropriate environmental niche for the bacterial survival and growth.

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Expression of bacterial virulence factors and cytokines during in vitro macrophage infection by enteroinvasive Escherichia coli and Shigella flexneri: a comparative study

Cited by 22 publications

References 30 publications

Recognition of enteroinvasive Escherichia coli and Shigella flexneri by dendritic cells: distinct dendritic cell activation states

Recognition of enteroinvasive Escherichia coli and Shigella flexneri by dendritic cells: distinct dendritic cell activation states

Recent Advances in Understanding Enteric Pathogenic Escherichia coli

Role of Virulence Factors on Host Inflammatory Response Induced by Diarrheagenic Escherichia Coli pathotypes

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