Serum hyaluronan and collagen IV as non-invasive markers of liver fibrosis in patients from an endemic area for schistosomiasis mansoni: a field-based study in Brazil

Marinho, Carolina Coimbra; Bretas, Thales; Voieta, Izabela; Queiroz, Leonardo Campos de; Ruiz-Guevara, Raiza; Teixeira, Antônio Lúcio; Antunes, Carlos; Prata, Áluízio; Lambertucci, José Roberto

doi:10.1590/s0074-02762010000400020

Cited by 23 publications

(20 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Hepatic stellate cell activation is the central event leading to hepatic fi brosis. In schistosomiasis, a series of serum markers of fi brosis has already been tested with different results: hyaluronic acid, different types of collagens, cytokines and components of the extracellular matrix, such as YKL-40 46,47 .…”

Section: Serum Markers Of Liver Fibrosismentioning

confidence: 99%

Revisiting the concept of hepatosplenic schistosomiasis and its challenges using traditional and new tools

Lambertucci

2014

Rev. Soc. Bras. Med. Trop.

Self Cite

View full text Add to dashboard Cite

Different aspects of hepatosplenic schistosomiasis are revisited here. Manson's schistosomiasis causes periportal fi brosis and portal hypertension in approximately 6% of infected subjects, usually with preservation of their hepatic function. The assessment of liver involvement is of major importance in determining the prognosis and risk of complications from schistosomiasis, such as upper digestive bleeding secondary to variceal rupture. For many years, the diagnosis of hepatosplenic schistosomiasis and liver fi brosis was made by abdominal palpation and the fi nding of liver and/or spleen enlargement. However, there is no consensus regarding the clinical parameters of the liver and spleen to be considered in this physical evaluation. For the last three decades, abdominal ultrasound (US) has become the best imaging technique to evaluate liver fi brosis caused by schistosomiasis mansoni. However, US is a subjective procedure and is therefore examiner-dependent. Magnetic resonance imaging (MRI) fi ndings have provided valuable information in addition to ultrasound and clinical examination. The combination of a comprehensive history and physical examination, basic laboratory tests (a stool examination for Schistosoma mansoni eggs and a blood cell count), biomarkers for liver fi brosis/portal hypertension and imaging methods seem to offer the best approach for evaluating patients with this disease. In situations where research is involved or in patients with severe disease, MRI may be considered.

show abstract

Section: Serum Markers Of Liver Fibrosismentioning

confidence: 99%

Revisiting the concept of hepatosplenic schistosomiasis and its challenges using traditional and new tools

Lambertucci

2014

Rev. Soc. Bras. Med. Trop.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Ricard-Blum et al (1999) found that serum concentrations of HA (but not those of type-I collagen or type-III pro-collagen) were markedly higher in (ultrasonography-evaluated) cases of PPF than in healthy controls, and suggested that serum concentrations of HA could be used to assess morbidity in schistosomiasis mansoni. More recently, Marinho et al (2010) reported how serum concentrations of HA (but not those of type-IV collagen) could be used to separate patients with light PPF from those with intense fibrosis. They also reported a positive correlation between serum HA concentrations and the prevalence of portal hypertension (as indicated by relatively large portal-and splenic-vein diameters) in patients with PPF caused by schistosomiasis mansoni.…”

Section: Discussionmentioning

confidence: 99%

“…As well as the proteins responsible for fibrogenesis, other molecules originating from the degradation of the extracellular matrix [e.g. hyaluronic acid (HA), type-III pro-collagen, type-IV collagen and laminin] have been used to assess liver fibrosis (Santos et al, 2005;Rossi et al, 2007;Marinho et al, 2010).…”

mentioning

confidence: 99%

Schistosomiasis mansoni: ultrasound-evaluated hepatic fibrosis and serum concentrations of hyaluronic acid

Silva

Domingues

Lopes

et al. 2011

Annals of Tropical Medicine & Parasitology

View full text Add to dashboard Cite

Schistosomiasis mansoni is a fibrogenic liver disease that constitutes a major health problem in north-eastern Brazil. Although one common manifestation of the disease, periportal fibrosis (PPF), can be assessed by ultrasonography by well-trained physicians, the necessary equipment and personnel are not always readily available. Serum markers, including hyaluronic acid (HA), have been used as alternative means of measuring fibrosis. Recently serum concentrations of HA have been evaluated in 77 Brazilians (61 cases of schistosomiasis mansoni and 16 healthy controls) and compared against the ultrasound-evaluated PPF in the same subjects. The HA was measured using a non-competitive fluorescence-based assay, while the PPF was explored using a portable ultrasound scanner (SSD-500; Aloka, Tokyo) and graded, as patterns A-F, according to the World Health Organization's 'Niamey protocol'. In general, the serum concentrations of HA were found to be positively correlated with the severity of the PPF. The mean concentration of HA in the sera of the 16 controls was significantly lower than that recorded in the schistosomiasis cases who showed PPF of patterns D or E (P,0.001 for each). The cases who showed pattern-C PPF also had significantly less HA in their sera than the cases with PPF of patterns D or E (P,0.001 for each), and the cases with pattern-D fibrosis had significantly lower HA concentrations in their sera than the cases with PPF of pattern E (P,0.001).In an analysis based on a receiver-operating-characteristic (ROC) curve, an HA concentration of 20.2 mg/litre of serum was identified as a threshold that could be used to distinguish moderate cases of PPF (i.e. patterns C or D) from the more advanced cases (i.e. patterns E or F), with a sensitivity of 60% and specificity of 65%.In conclusion, it appears that serum concentrations of hyaluronic acid could be used as markers for periportal fibrosis in patients with schistosomiasis mansoni.Although the human morbidity and mortality caused by schistosomiasis mansoni have been reduced over the last 25 years by chemotherapy, the disease still represents a significant health hazard, particularly in north-eastern Brazil (Katz and Peixoto, 2000;Araú jo et al., 2007).It is believed that between 2% and 7% of humans infected with Schistosoma mansoni go on to develop hepato-splenic disease, which is associated with portal hypertension and digestive bleeding brought on by the rupture of oesophageal varices or hypertensive

show abstract

“…All of these markers (HA, platelets, APRI, GGT) showed a correlation to portal hypertension (Mansour et al 1982, Souza et al 2000, Marinho et al 2010.…”

Section: Gama Glutamyl Transpeptidase (Ggt) -Some Studiesmentioning

confidence: 97%

“…Marinho et al (2010) evaluating serum levels of HA and type IV collagen with respect to ultrasonographic patterns of PPF, showed that only the serum HA levels were capable of separating patients with mild fibrosis from those with intense fibrosis. These authors also reported a positive correlation between HA serum levels and signs of portal hypertension (using portal and splenic vein diameters).…”

Section: Serum Type VI Collagenmentioning

confidence: 99%

Ultrasound versus biological markers in the evaluation of periportal fibrosis in human Schistosoma mansoni

Domingues

Medeiros

Lopes

2011

Mem. Inst. Oswaldo Cruz

View full text Add to dashboard Cite

Serum hyaluronan and collagen IV as non-invasive markers of liver fibrosis in patients from an endemic area for schistosomiasis mansoni: a field-based study in Brazil

Abstract: Non-invasive markers of fibrosis have been used to diagnose liver fibrosis in a variety of diseases. Hyaluronic acid (HA) and collagen IV (C-IV

Cited by 23 publications

References 67 publications

Revisiting the concept of hepatosplenic schistosomiasis and its challenges using traditional and new tools

Revisiting the concept of hepatosplenic schistosomiasis and its challenges using traditional and new tools

Schistosomiasis mansoni: ultrasound-evaluated hepatic fibrosis and serum concentrations of hyaluronic acid

Ultrasound versus biological markers in the evaluation of periportal fibrosis in human Schistosoma mansoni

Contact Info

Product

Resources

About