2010
DOI: 10.1590/s0074-02762010000300001
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Abstract: Trypanosoma cruzi is a parasite that causes Chagas disease, which affects millions of individuals in endemic areas of Latin America. One hundred years after the discovery of Chagas disease, it is still considered a neglected illness because the available drugs are unsatisfactory. Aromatic compounds represent an important class of DNA minor groove-binding ligands that exhibit potent antimicrobial activity. This study focused on the in vitro activity of 10 aromatic dicationic compounds against bloodstream trypom… Show more

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Cited by 11 publications
(10 citation statements)
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References 24 publications
(21 reference statements)
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“…A greater sensitivity of the amastigote form of T. cruzi has also been observed by other researchers using in vitro assays (da Silva et al 2010). The in vitro activity of two of these compounds (6 and 7) against both proliferative stages of T. cruzi was superior to the positive control benznidazole (Table); in contrast, three exhibited similar potencies (1, 2 and 5) and two were substantially less potent (3 and 4).…”
Section: Resultssupporting
confidence: 75%
See 1 more Smart Citation
“…A greater sensitivity of the amastigote form of T. cruzi has also been observed by other researchers using in vitro assays (da Silva et al 2010). The in vitro activity of two of these compounds (6 and 7) against both proliferative stages of T. cruzi was superior to the positive control benznidazole (Table); in contrast, three exhibited similar potencies (1, 2 and 5) and two were substantially less potent (3 and 4).…”
Section: Resultssupporting
confidence: 75%
“…The results showed that the tested compounds displayed higher activities against the T. cruzi culture form (IC 50 values ranging from 2.46-18.31 µM) ( Table ), being at least 10-fold more active compared to the previous data observed for the bloodstream form ( Júnior et al 2010 ). A greater sensitivity of the amastigote form of T. cruzi has also been observed by other researchers using in vitro assays (da Silva et al 2010 ). The in vitro activity of two of these compounds (6 and 7) against both proliferative stages of T. cruzi was superior to the positive control benznidazole ( Table ); in contrast, three exhibited similar potencies (1, 2 and 5) and two were substantially less potent (3 and 4).…”
Section: Resultssupporting
confidence: 75%
“…Recent published data from our group showed that, similarly to observations with T. brucei, diamidines also are accumulated within DNA-free organelles, possibly acidocalcisomes (3), which are acidic organelles that play roles in a number of cellular processes, such as the storage of cations and phosphorus, calcium homeostasis, the maintenance of intracellular pH, and osmoregulation (14). Additionally, although diamidines are localized within the nuclei and kDNA of T. cruzi, their higher accumulation in the latter structure does not predict compound efficacy in vitro (5,8).…”
Section: Discussionmentioning
confidence: 99%
“…Parasitemia was individually checked by direct microscopic counting of parasites in 5 l of blood, as described before (34). At different time points, body weight was evaluated.…”
Section: Methodsmentioning
confidence: 99%