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Cited by 19 publications
(12 citation statements)
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“…Based upon observations in human infection and in experimental models, it is currently accepted that T cells play an important role not only in controlling parasite burden but also modulating disease progression [13]. During the chronic phase of the disease, in its asymptomatic or cardiac manifestation forms, CD8 + T cells are believed to be involved in both parasite control and in tissue damage, which contributes to cardiac alterations.…”
Section: Introductionmentioning
confidence: 99%
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“…Based upon observations in human infection and in experimental models, it is currently accepted that T cells play an important role not only in controlling parasite burden but also modulating disease progression [13]. During the chronic phase of the disease, in its asymptomatic or cardiac manifestation forms, CD8 + T cells are believed to be involved in both parasite control and in tissue damage, which contributes to cardiac alterations.…”
Section: Introductionmentioning
confidence: 99%
“…On the other hand, CD4 + T cells and monocytes/macrophages participate in the secretion of both inflammatory and anti-inflammatory cytokines, and this release correlates with the clinical outcome of the disease [2,3]. In general, peripheral blood mononuclear cells (PBMC) from cardiac chagasic patients produce more IFN-γ and less IL-10 than do those from asymptomatic patients [810].…”
Section: Introductionmentioning
confidence: 99%
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“…Few investigations have been focused on the reactivity of T cells against purified antigens of the parasite [30]–[40]. To date, studies performed with recombinant parasite proteins, such as the cytoplasmatic repetitive antigen (CRA), B13, trans-sialidase, and paraflagellar rod proteins on PBMC and cruzipain on T cells lines revealed that patients with CCC produced significant amount of IFN-γ upon stimulation, which is in line with the typical pattern of inflammatory response described for T. cruzi lysate [34]–[40].…”
Section: Introductionmentioning
confidence: 99%
“…Host peptidase inhibitors such as -2-macroglobulin ( -2M) and kininogens interact with T. cruzi cruzipain in extravascular infection sites, linking inflammation to innate immunity by different mechanisms [70]. Cruzipain has the ability to generate kinin released from kininogens due to its activity of 'kininogenase' [71,72].…”
Section: C14mentioning
confidence: 99%