2009
DOI: 10.1590/s0074-02762009000400002
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Abstract: Treatments for Chagas disease have been administered since the first attempts by Mayer & Rocha Lima (1912, 1914

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Cited by 124 publications
(99 citation statements)
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References 28 publications
(21 reference statements)
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“…Several clinical studies have been conducted and hundreds of patients have been treated with nifurtimox or benznidazole, with variations in the results between the studies and the regions where they were carried out. The average cure rate among acute and recent cases is 80%, while it is less than 20% among chronic cases [23][24][25] . A pilot study, the Benefit project -Benznidazole Evaluation for Interruping Trypanosomiasis -an international, multicenter, double-bind, placebo-controlled trial of tripanocidal chronic Chagas heart disease is in course 40,41 .…”
Section: Drugs In Use and New Strategies For Treating Chagas Diseasementioning
confidence: 99%
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“…Several clinical studies have been conducted and hundreds of patients have been treated with nifurtimox or benznidazole, with variations in the results between the studies and the regions where they were carried out. The average cure rate among acute and recent cases is 80%, while it is less than 20% among chronic cases [23][24][25] . A pilot study, the Benefit project -Benznidazole Evaluation for Interruping Trypanosomiasis -an international, multicenter, double-bind, placebo-controlled trial of tripanocidal chronic Chagas heart disease is in course 40,41 .…”
Section: Drugs In Use and New Strategies For Treating Chagas Diseasementioning
confidence: 99%
“…It was also recommended that children up to the age of 12 years should be treated, as well as cases of recent infection in adults over known periods within the last 10 to 12 years. Coura 24 reviewed those recommendations and suggested that combinations of drugs, such as benznidazole + nifurtimox, and benznidazole or nifurtimox + antifungals that inhibit ergosterol in double or triple associations should be used, as is done with drugs for treating tuberculosis, leprosy and human immunodeficiency virus/ acquired mmunodeficiency syndrome (HIV/AIDS). More recently, on the basis on the pathogenesis of the disease and its evolution, Coura & Borges-Pereira 25 recommended that the treatment should be broadened to chronic cases at initial evolutionary stages, such as stage II of the New York Heart Association 26 and up to stage III, at the discretion of the attending doctor and with the patient's agreement.…”
Section: Drugs In Use and New Strategies For Treating Chagas Diseasementioning
confidence: 99%
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“…In addition, it is a parasitic disease with greater a economic burden on the Americas due to its long chronicity. This is why Chagas disease represents the second highest disease burden among tropical diseases in the Americas (Coura, 2009;Coura and Dias, 2009).…”
Section: Epidemiologic Approach To Chagas Disease: Importance Of the mentioning
confidence: 99%
“…This can be done through sensitive methods such as immunohistochemistry, polymerase chain reaction (PCR), and in situ hybridization (Britto, 2009;Deborggraeve et al, 2009;Duffy et al, 2009;Rassi et al, 2009a;Rassi and Rassi, 2009;Rassi et al, 2009c). Experimentally, this is demonstrated by attenuation of cardiomyopathy with parasite load reduction by trypanocidal treatment (Britto, 2009;Bustamante et al, 2008;Coura, 2009;Marin-Neto et al, 2009;Perez-Molina et al, 2009;Urbina, 2009b;Viotti et al, 2009). However, myocardial inflammatory infiltrates and lesions are not uniformly reduced in mice infected with different T. cruzi strains and treated with benznidazole (Bz) (Caldas et al, 2008;MarinNeto et al, 2009;Rassi and Rassi, 2009).…”
Section: Myocardial Damage Directly Related To Parasite Persistencementioning
confidence: 99%