Prenatal screening for congenital toxoplasmosis in Campania: preliminary report on activities and results

Stagni, L; Romano, Mercedes; Romano, Amelia; Magli, Adriano; Briganti, Francesco; Pezzo, Mariassunta Del; Buffolano, Wilma

doi:10.1590/s0074-02762009000200035

Cited by 18 publications

(12 citation statements)

References 6 publications

(4 reference statements)

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“…This prevalence is considered high in comparison to that observed in other countries where neonatal screening programs for congenital toxoplasmosis have been implemented; these countries include Poland (4.7/10,000) 9 , Sweden (0.73/10,000) 10 , Italy (1.38/10,000) 11 and Denmark (1.6/10,000) 12 . However, the prevalence observed herein is lower than that observed in México (20/10,000) 13 .…”

Section: Conflict Of Interest Financial Support References Neonatal Smentioning

confidence: 81%

Incidence of congenital toxoplasmosis in the city of Belém, state of Pará, northern Brazil, determined by a neonatal screening program: preliminary results

Bichara

Canto

Tostes

et al. 2012

Rev. Soc. Bras. Med. Trop.

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Revista da Sociedade Brasileira de MedicinaABSTRAcT Introduction: The aim of this study was to determinate the incidence of congenital toxoplasmosis among a group of newborns (NBs) from Belém using neonatal screening. Methods: Among the 6,000 newborns referred for investigation of genetic and metabolic diseases, 1,000 were selected for screening for congenital toxoplasmosis by determining the amount of IgM in the eluates of blood collected on filter paper. Positive tests were confirmed using paired serology of the NB and his mother. Results: Out of the 1,000 NBs assessed, one had a positive screening result that was confirmed by paired serology. conclusions: The incidence of congenital toxoplasmosis in Belém was 10/10,000 live NBs.

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Section: Conflict Of Interest Financial Support References Neonatal Smentioning

confidence: 81%

Incidence of congenital toxoplasmosis in the city of Belém, state of Pará, northern Brazil, determined by a neonatal screening program: preliminary results

Bichara

Canto

Tostes

et al. 2012

Rev. Soc. Bras. Med. Trop.

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“…In Italy, the surveillance system for congenital toxoplasmosis, reporting data on live newborns from mothers with gestational toxoplasmosis, is active on a regional basis (e.g. Campania region) [27]. However, a nationwide epidemiological surveillance system for congenital toxoplasmosis is still lacking [1].…”

Section: Introductionmentioning

confidence: 99%

Toxoplasma gondii in women of childbearing age and during pregnancy: seroprevalence study in Central and Southern Italy from 2013 to 2017

et al. 2020

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Toxoplasmosis is a worldwide health problem. Infection in pregnant women can result in severe fetal morbidity or in subclinical neonatal infection; most subclinical cases develop ocular and neurological sequelae. The purpose of this serological study was to assess the prevalence of Toxoplasma gondii in two populations of women of childbearing age in Siena (Tuscany, Central Italy) and Bari (Apulia, Southern Italy) between 2013 and 2017 and in a group of pregnant women in Bari in 2016–2017. Serum samples were tested for the presence of specific anti-Toxoplasma gondii IgG antibodies by a commercially available ELISA test. The percentage of seropositive subjects in Bari was significantly higher than in Siena (22.4% vs. 12.4%) and an age-related trend was observed. A low prevalence of T. gondii infection (13.8%) was observed among the pregnant women tested. In addition to showing a significant difference between Central and Southern Italy, this study provides updated data on T. gondii seroprevalence in women during childbearing age and pregnancy. The results confirm a trend toward a decrease, especially in younger people and pregnant women.

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“…In Italy, a nationwide epidemiological surveillance system for toxoplasmosis is still lacking, although surveillance is available on a regional basis [20,21]. Serological tests for toxoplasmosis are performed as a routine prenatal screening during pregnancy, with a first evaluation at the 13th week, followed by monthly testing of pregnant women who are seronegative for toxoplasmosis (total 5-7 tests), as indicated by Italian legislation.…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence for toxoplasmosis in individuals living in North West Tuscany: access to Toxo-test in central Italy

Pinto

Castagna

Mattei³

et al. 2011

Eur J Clin Microbiol Infect Dis

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This survey aimed to estimate the prevalence of anti-Toxoplasma IgG and IgM antibodies in people living in north west Tuscany (central Italy) and to investigate the adherence to antenatal screening programs and access to the Toxo-test as well. Sera from a large sample of individuals suspected to have acute infection or from pregnant women (10,352 subjects) aged between 1 day and over 70 years were analysed for both IgG and IgM anti-Toxoplasma antibodies using an immunoenzymatic method or a chemo-luminescent immunoassay. Overall, the seroprevalence of IgG antibodies was 21.4% (95% CI 20.62-22.20). A positive trend according to age was found, with low positivity observed in younger age groups. Among women of reproductive age the prevalence of IgG antibodies was 19.4% (95% CI 18.64-20.26). The overall IgM seroprevalence was 1.07% (95% CI 0.87-1.27). A low IgM prevalence was also observed in women of reproductive age (0.8%; 95% CI 0.65-1.03). Our study seems to indicate that primary prevention is widespread among women. However, an epidemiological surveillance system for toxoplasmosis should be implemented, to assess the risk of congenital toxoplasmosis and to determine the true burden of disease in adults.

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Prenatal screening for congenital toxoplasmosis in Campania: preliminary report on activities and results

Cited by 18 publications

References 6 publications

Incidence of congenital toxoplasmosis in the city of Belém, state of Pará, northern Brazil, determined by a neonatal screening program: preliminary results

Incidence of congenital toxoplasmosis in the city of Belém, state of Pará, northern Brazil, determined by a neonatal screening program: preliminary results

Toxoplasma gondii in women of childbearing age and during pregnancy: seroprevalence study in Central and Southern Italy from 2013 to 2017

Seroprevalence for toxoplasmosis in individuals living in North West Tuscany: access to Toxo-test in central Italy

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