Urban transmission of Chagas disease in Cochabamba, Bolivia

Medrano-Mercado, Nora; Ugarte-Fernandez, R; Butrón,; Uber-Busek, S; Hl, Guerra; Araújo-Jorge, Tânia C.; Correa-Oliveira, Rodrigo

doi:10.1590/s0074-02762008000500003

Cited by 66 publications

(54 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…63 Another alternative to explain these results is that residual domiciliary populations of T. infestans might be playing a role in house reinfestation after the spraying campaign. However, in our case, insects found inside dwellings do not represent a recolonization because only adults have been found, although, that event might occur, given that adults of both sexes and/or fertilized females invade domestic habitats, as occurred with T. infestans in Bolivia 64 and with Rhodnius prolixus from different habitats in Venezuela after control campaigns. 65 In this new epidemiologic scenario, the risk of human dwelling re-infestation depends on the presence of sylvatic foci of T. infestans within their natural habitat, in this case, the bromeliad Puya sp., which provides refuge to mammals and to T. infestans colonies.…”

Section: Discussionmentioning

confidence: 58%

Differential Pattern of Infection of Sylvatic Nymphs and Domiciliary Adults of Triatoma infestans with Trypanosoma cruzi Genotypes in Chile

Bacigalupo¹,

Segovia²,

García³

et al. 2012

The American Journal of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

Abstract. In Chile, the main vector of Chagas disease, Triatoma infestans, is under control after insecticide spraying. However, it has been found colonizing wild habitats. This study evaluated Trypanosoma cruzi infection of sylvatic and domiciliary T. infestans and identified their parasite genotypes. The sample studied was composed mainly of T. infestans sylvatic nymphs and domiciliary adults from a semi-urban area with human dwellings under vector control surveillance. Results showed prevalences of 57.7% in nymphs and 68.6% in adults. Hybridization tests showed a major T. cruzi lineage (TcI) circulating in sylvatic (93.3%) and domiciliary (100%) T. infestans. TcII, TcV, and TcVI were also detected, mainly in nymphs, suggesting differential adaptation of T. cruzi lineages among instars. We also discuss the origin of domiciliary individuals of T. infestans and the risk of human infection by triatomines of sylvatic foci that invade houses despite vector control programs.

show abstract

Section: Discussionmentioning

confidence: 58%

Differential Pattern of Infection of Sylvatic Nymphs and Domiciliary Adults of Triatoma infestans with Trypanosoma cruzi Genotypes in Chile

Bacigalupo¹,

Segovia²,

García³

et al. 2012

The American Journal of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

show abstract

“…In areas of Cochabamba, Bolívia, T. cruzi infection is now considered an urban health problem and is no longer restricted to rural areas and small villages. The high infection risk in children was correlated to the high percentage of the natural infection rates of the vector and qualitative and quantitative evidence for the current active transmission of T. cruzi in urban areas of Cochabamba was demonstrated (Medrano-Mercado et al 2008).…”

Section: Biology Diversity and Strategies For The Monitoring And Conmentioning

confidence: 97%

Biology, diversity and strategies for the monitoring and control of triatomines - Chagas disease vectors

Costa¹,

Lorenzo²

2009

Mem. Inst. Oswaldo Cruz

View full text Add to dashboard Cite

show abstract

“…Chagas disease is endemic across two‐thirds of the country and concentrated disproportionally among lower socio‐economic rural populations with seroprevalence reaching 72.7–97.1% among adults of some communities (Medrano‐Mercado et al . 2008; Samuels et al . 2013).…”

Section: Introductionmentioning

confidence: 99%

Ecological host fitting of Trypanosoma cruzi TcI in Bolivia: mosaic population structure, hybridization and a role for humans in Andean parasite dispersal

et al. 2015

View full text Add to dashboard Cite

An improved understanding of how a parasite species exploits its genetic repertoire to colonize novel hosts and environmental niches is crucial to establish the epidemiological risk associated with emergent pathogenic genotypes. Trypanosoma cruzi, a genetically heterogeneous, multi‐host zoonosis, provides an ideal system to examine the sylvatic diversification of parasitic protozoa. In Bolivia, T. cruzi I, the oldest and most widespread genetic lineage, is pervasive across a range of ecological clines. High‐resolution nuclear (26 loci) and mitochondrial (10 loci) genotyping of 199 contemporaneous sylvatic TcI clones was undertaken to provide insights into the biogeographical basis of T. cruzi evolution. Three distinct sylvatic parasite transmission cycles were identified: one highland population among terrestrial rodent and triatomine species, composed of genetically homogenous strains (A r = 2.95; PA/L = 0.61; DAS = 0.151), and two highly diverse, parasite assemblages circulating among predominantly arboreal mammals and vectors in the lowlands (A r = 3.40 and 3.93; PA/L = 1.12 and 0.60; DAS = 0.425 and 0.311, respectively). Very limited gene flow between neighbouring terrestrial highland and arboreal lowland areas (distance ~220 km; FST = 0.42 and 0.35) but strong connectivity between ecologically similar but geographically disparate terrestrial highland ecotopes (distance >465 km; FST = 0.016–0.084) strongly supports ecological host fitting as the predominant mechanism of parasite diversification. Dissimilar heterozygosity estimates (excess in highlands, deficit in lowlands) and mitochondrial introgression among lowland strains may indicate fundamental differences in mating strategies between populations. Finally, accelerated parasite dissemination between densely populated, highland areas, compared to uninhabited lowland foci, likely reflects passive, long‐range anthroponotic dispersal. The impact of humans on the risk of epizootic Chagas disease transmission in Bolivia is discussed.

show abstract

Urban transmission of Chagas disease in Cochabamba, Bolivia

Abstract: Chagas disease is a major public health problem in Bolivia. In the city of Cochabamba, 58% of the population lives in peripheral urban districts ("popular zones")

Cited by 66 publications

References 15 publications

Differential Pattern of Infection of Sylvatic Nymphs and Domiciliary Adults of Triatoma infestans with Trypanosoma cruzi Genotypes in Chile

Differential Pattern of Infection of Sylvatic Nymphs and Domiciliary Adults of Triatoma infestans with Trypanosoma cruzi Genotypes in Chile

Biology, diversity and strategies for the monitoring and control of triatomines - Chagas disease vectors

Ecological host fitting of Trypanosoma cruzi TcI in Bolivia: mosaic population structure, hybridization and a role for humans in Andean parasite dispersal

Contact Info

Product

Resources

About