The effects of fluconazole and cytokines on human mononuclear cells

Fidan, Işıl; Yüksel, Sevgi; İmir, Turgut; Kalkancı, Ayşe; Kuştımur, Semra; İlhan, Mustafa

doi:10.1590/s0074-02762007005000021

Cited by 8 publications

(6 citation statements)

References 17 publications

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“…Several papers describing the activity of antifungal drugs on the immune system have been published, most based on in vitro studies [7][8][9][10]. Regarding the immunomodulatory effects of azoles, the results have been conflicting.…”

Section: Discussionmentioning

confidence: 99%

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Immunomodulatory activity of itraconazole in lung

Naranjo¹,

Henao²,

Zuluaga³

et al. 2017

Trop. J. Pharm Res

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Section: Discussionmentioning

confidence: 99%

“…Fidan et al [10] showed that fluconazole, an antifungal drug used frequently to treat Candida infections, increased the levels of chemokines, such as CCL3 and CCL4, in the supernatants of human mononuclear cell cultures.…”

Section: Introductionmentioning

confidence: 99%

Immunomodulatory activity of itraconazole in lung

Naranjo¹,

Henao²,

Zuluaga³

et al. 2017

Trop. J. Pharm Res

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“…In this context, we decided to use PBMC as a predictive model to investigate toxicity and immunomodulatory effects. We considered using this model because invasive fungal infections cause high rates of mortality and morbidity in immunocompromised patients, demonstrating the necessity of an effective immune response to control fungal infections 28 . Peripheral blood mononuclear cells play a very important role in the defence against fungal infection via both phagocytosis and other cellular immune responses 28 .…”

Section: Discussionmentioning

confidence: 99%

“…We considered using this model because invasive fungal infections cause high rates of mortality and morbidity in immunocompromised patients, demonstrating the necessity of an effective immune response to control fungal infections 28 . Peripheral blood mononuclear cells play a very important role in the defence against fungal infection via both phagocytosis and other cellular immune responses 28 . In this regard, pseudodillapiol proved to be, on the face of it, innocuous in the assay with PBMC, showing a potentially selective effect towards these pathogens and a lack of toxic effects to cells of the immune system.…”

Section: Discussionmentioning

confidence: 99%

“…28 Peripheral blood mononuclear cells play a very important role in the defence against fungal infection via both phagocytosis and other cellular immune responses. 28 In this regard, pseudodillapiol proved to be, on the face of it, innocuous in the assay with PBMC, showing a potentially selective effect towards these pathogens and a lack of toxic effects to cells of the immune system. Therefore, our results reveal that pseudodillapiol may serve as a starting point for further development of new antifungal medicines.…”

Section: Discussionmentioning

confidence: 99%

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Antifungal activities of compounds isolated from Piper abutiloides Kunth

Johann

Cota

Souza-Fagundes

et al. 2009

Mycoses

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Piperaceae is a family of tropical plants known to have antifungal, antibacterial, tumour-inhibitory, antiviral, antioxidant, molluscicidal and leishmanicidal activities. In this work, extracts and fractions from aerial parts of Piper abutiloides (Piperaceae), a traditional medicinal plant, were evaluated against the fungal species Candida albicans, C. parapsilosis, C. krusei, C. glabrata, C. tropicalis, Cryptococcus neoformans and Sporothrix schenckii. The results have shown that the antifungal activity of this plant can be concentrated in the hexanic fraction after partitioning its hydroalcoholic extract between hexane and 90% aqueous methanol. The chromatographic fractionation of the bioactive part was monitored with a bioautographic assay using C. glabrata, and allowed the isolation of three antifungal compounds: pseudodillapiol, eupomatenoid-6 and conocarpan. These compounds presented different potencies against the fungi tested, with the strongest effect being observed for eupomatenoid-6 against C. glabrata, which presented a minimal inhibitory concentration value of 0.3 microg spot(-1). Conocarpan showed antifungal activity without apparent cytotoxic effect on normal human lymphocytes, as assessed by the proliferation assay with human peripheral blood mononuclear cells stimulated with phytohaemaglutinin. This work reveals for the first time the occurrence of these compounds in P. abutiloides and justifies further studies to clarify their mechanisms of action.

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Gene expression profile and long noncoding RNA analysis in Candida albicans insoluble β-glucan-stimulated CD14+ monocytes and THP-1 cells

Hou

et al. 2021

Microbial Pathogenesis

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The effects of fluconazole and cytokines on human mononuclear cells

Cited by 8 publications

References 17 publications

Immunomodulatory activity of itraconazole in lung

Immunomodulatory activity of itraconazole in lung

Antifungal activities of compounds isolated from Piper abutiloides Kunth

Gene expression profile and long noncoding RNA analysis in Candida albicans insoluble β-glucan-stimulated CD14+ monocytes and THP-1 cells

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