2006
DOI: 10.1590/s0074-02762006000900059
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: We have previously showed that Schistosoma mansoni ATP-diphosphohydrolase and Solanum tuberosum potato apyrase share epitopes and the vegetable protein has immunostimulatory properties. Here, it Recently, two actives ATP diphosphohydrolase isoforms were partially purified from Schistosoma mansoni egg (Faria-Pinto et al. 2004). These enzymes, previously detected on the external surface of schistosomula and worm adult tegument (Vasconcelos et al. 1996, De Marco et al. 2003, hydrolyze di-and triphosphate nucle… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
8
0

Year Published

2007
2007
2012
2012

Publication Types

Select...
7
1

Relationship

0
8

Authors

Journals

citations
Cited by 12 publications
(8 citation statements)
references
References 13 publications
0
8
0
Order By: Relevance
“…Region B from these parasites is of particular interest, since it has lower homology with mammalian proteins and could be responsible for the antibody reactivity described here. In previous work we demonstrated by immunocytochemistry and confocal microscopy that rabbit polyclonal antibodies to potato apyrase recognize ATP diphosphohydrolase isoforms from S. mansoni egg, but not the mammalian NTPDases, suggesting the presence of unique motifs shared between the parasite and the vegetable protein, and that autoantibodies are not induced by potato apyrase immunization (Faria-Pinto et al 2006).…”
Section: Discussionmentioning
confidence: 91%
“…Region B from these parasites is of particular interest, since it has lower homology with mammalian proteins and could be responsible for the antibody reactivity described here. In previous work we demonstrated by immunocytochemistry and confocal microscopy that rabbit polyclonal antibodies to potato apyrase recognize ATP diphosphohydrolase isoforms from S. mansoni egg, but not the mammalian NTPDases, suggesting the presence of unique motifs shared between the parasite and the vegetable protein, and that autoantibodies are not induced by potato apyrase immunization (Faria-Pinto et al 2006).…”
Section: Discussionmentioning
confidence: 91%
“…In addition, a recombinant form of the T. gondii NTPase II elicits a strong humoral and cellular immune responses in BALB/c mice inducing partial protection against virulent T. gondii strains, and it was indicated as an effective candidate for the development of a vaccine against toxoplasmosis (Tan et al, 2011). Rabbit polyclonal anti-potato apyrase antibodies (Faria-Pinto et al, 2006) or mouse polyclonal antibodies against a synthetic peptide (r175-194) belonging to the domain B from the Schistosoma mansoni ATP-Dase 2 (Mendes et al, 2011) did not recognize mammalian NTPDases, corroborated by the lower identity found between domains B from either potato apyrase or parasites and mammalian NTPDases (Faria-Pinto et al, 2008;Maia et al, 2011). We hypothesize that the synthetic peptides LbB1LJ or LbB2LJ, or its derivatives, could induce immune response capable to inhibit invading promastigote forms, and could be tested in experimental protocols of vaccine.…”
Section: Discussionmentioning
confidence: 99%
“…1996, Levano‐Garcia et al. 2007) and show cross‐immunoreactivity with potato apyrase antibodies (Faria‐Pinto et al. 2006, 2008).…”
Section: Invertebratesmentioning
confidence: 99%