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Cited by 11 publications
(6 citation statements)
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“…In the current review, all negative sera were obtained from schistosomiasis unexposed individuals without Schistosoma infections and without a history of contact with contaminated water. Negative controls can be differentiated into normal negative controls (from healthy individuals) or specificity controls from individuals (from individuals infected with other parasites) [ 35 , 41 , 42 , 45 ]. Specificity controls are important to determine whether a test can designate an individual who do not have the target infection as negative.…”
Section: Resultsmentioning
confidence: 99%
“…In the current review, all negative sera were obtained from schistosomiasis unexposed individuals without Schistosoma infections and without a history of contact with contaminated water. Negative controls can be differentiated into normal negative controls (from healthy individuals) or specificity controls from individuals (from individuals infected with other parasites) [ 35 , 41 , 42 , 45 ]. Specificity controls are important to determine whether a test can designate an individual who do not have the target infection as negative.…”
Section: Resultsmentioning
confidence: 99%
“…This is due to the inability to accurately differentiate between active infection, past infection, and reinfection; and also because of antibody cross-reactivity with different helminth species [48]. In terms of increasing the specificity of antibody-based immunodiagnostics, the search for new antigens has been proposed [44, 45, 73, 74]. Most of the antigens described in the literature are related to the crude extracts (SEA and SWAP) which have a complex source, require time-consuming purification steps, and vary greatly on accuracy and reproducibility [37, 48].…”
Section: Discussionmentioning
confidence: 99%
“…Recently, recombinant antigens [ 41 , 67 69 ] and synthetic peptides [ 70 ] have been used in order to increase the specificity of serological tests. One recombinant antigen that has been widely used for identifying patients with low parasite burdens is CCA (circulating cathodic antigen) [ 69 ].…”
Section: Discussionmentioning
confidence: 99%