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Cited by 7 publications
(7 citation statements)
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References 8 publications
(5 reference statements)
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“…Furthermore, the expressions of CCR5 were increased in PZQ treatment groups. This feature suggested that CCR5 plays a crucial role in fibrotic liver of schistosomiasis as other research reported [28] and the function of CCR5 may be partly attributed to its expression on HSCs. Besides, CCR5 is also expressed on activated T cells and regulatory T cells, which regulate the immune response and control the immunopathology of the schistosomiasis [29].…”
Section: Discussionsupporting
confidence: 69%
See 1 more Smart Citation
“…Furthermore, the expressions of CCR5 were increased in PZQ treatment groups. This feature suggested that CCR5 plays a crucial role in fibrotic liver of schistosomiasis as other research reported [28] and the function of CCR5 may be partly attributed to its expression on HSCs. Besides, CCR5 is also expressed on activated T cells and regulatory T cells, which regulate the immune response and control the immunopathology of the schistosomiasis [29].…”
Section: Discussionsupporting
confidence: 69%
“…However, conflicting results were also reported in different liver fibrosis models such as schistosomiasis mice. The CCR5 −/− mice developed a more severe pathological damage than wild type mice in schistosomiasis mansoni [28]. In our data, expression of CCR5 on HSCs was not changed at 3 weeks p.i , but unexpectedly decreased at 6 weeks p.i , and maintained a low level during chronic stages.…”
Section: Discussionmentioning
confidence: 40%
“…Stellate liver cells (Kupffer cells), which are mediators of liver fibrosis, are activated by tumor necrosis factor-alpha (TNF-α), platelet-derived growth factor (PDGF) and fibrogenic cytokines, such as TGF-β, IL-13, angiotensin II and (2,14,15) . Besides the proteins responsible for fibrogenesis others stemming from the degradation process of the extracellular matrix have been studied in the evaluation of fibrosis, such as hyaluronic acid, laminin and type IV collagen (10,16,19,27) .…”
Section: Correlation Between Platelet Count and Both Liver Fibrosis Amentioning
confidence: 99%
“…Com a intenção de contornar as desvantagens da biopsia do fígado, mormente por constituir método invasivo e estar sujeito a erros de amostragem, nos últimos anos algumas substâncias envolvidas na produção ou degradação do colágeno vêm sendo avaliadas, tanto isoladamente como em conjunto, compondo os chamados índices, na avaliação da fibrose que se desenvolve nas doenças crônicas do fígado (9,14,16,20) .…”
Section: Discussionunclassified