2006
DOI: 10.1590/s0074-02762006000900049
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Abstract: -(4-methoxi-benzylidene)-2-thioxo-imidazolidin-4-one JT69; 3-(4-phenyl-benzyl)-1-methyl-5-(4-methoxi-benzylidene)-2-thioxo-imidazolidin-4-one

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Cited by 19 publications
(13 citation statements)
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References 11 publications
(7 reference statements)
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“…In comparison to the literature findings, it was also observed that heterocyclic compounds containing a methoxyl group exhibited higher schistosomicidal activity than compounds without this group (47). Another interesting structure-activity relationship is observed for the compound LpQM-47, which produced a mortality rate of 95% at 100 g · ml Ϫ1 and 91% at 60 g · ml Ϫ1 after 192 h of incubation.…”
Section: Discussionsupporting
confidence: 44%
“…In comparison to the literature findings, it was also observed that heterocyclic compounds containing a methoxyl group exhibited higher schistosomicidal activity than compounds without this group (47). Another interesting structure-activity relationship is observed for the compound LpQM-47, which produced a mortality rate of 95% at 100 g · ml Ϫ1 and 91% at 60 g · ml Ϫ1 after 192 h of incubation.…”
Section: Discussionsupporting
confidence: 44%
“…However, similar to praziquantel, the mechanism by which the imidazolidines exert schistosomicide activity in vitro is still unclear. So far, the main activities assigned to imidazolidines are antibacterial, antiamebic, anti-T. cruzi and anti-schistosomic (Kalyaham et al 1992;Sharma and Khan 2001;Pitta et al 2006;Caterina et al 2008). Imidazolidines also show activity in apoptotic cells with melanoma, whose route was identified in S. mansoni (Dubois et al 2009) and has been suggest as the result, possibly, of activity at the cholinergic level receptors, since the nervous system of S. mansoni, with its unique pharmacological and physiological characteristics, can be used to research compounds for human and animal use.…”
Section: Discussionmentioning
confidence: 99%
“…These compounds have been used as anti-schistosome agents in previous studies by our group Albuquerque et al 2005;Pitta et al 2006). Here, we investigated the action of new imidazolidine derivatives 5-(4-chloro-benzylidene-3-(4-nitrebenzyl)-4-thioxo-imidazolidin-2-one (Laboratório de Planejamento de Síntese de Fármacos (LPSF)/RZS-2) and 5-(4-fluoridebenzylidene-3-(4-nitrebenzyl)-4-thioxo-imidazolidin-2-one (LPSF/RZS-5) against Schistosoma mansoni adult worms.…”
Section: Introductionmentioning
confidence: 99%
“…The latter activity of imidazolidine derivatives has been demonstrated by in vitro studies with adult S. mansoni worms. However, as for PZQ, the mechanism of action of the imidazolidines has not yet been fully elucidated 18 , 19 .…”
Section: Introductionmentioning
confidence: 99%