The effects of drugs, ions, and poly-l-lysine on the excretory system of Schistosoma mansoni

Kusel, J. R.; Oliveira, Fabrícia Alvisi de; Todd, Matthew H.; Ronketti, Fiona; Lima, S.F.; Mattos, A C A; Reis, Kátia Teixeira dos; Coelho, P. M. Z.; Thornhill, J.; Ribeiro, Fábio

doi:10.1590/s0074-02762006000900046

Cited by 23 publications

(31 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, it appears that alpha-humulene and trans-caryophyllene acts only on the excretory system of male worms, inhibiting Pgp expression and presenting themselves as potential schistosomicidal agents. Other authors attained similar results when they evaluated PZQ interaction with S. mansoni excretory system [25,28].…”

Section: Discussionsupporting

confidence: 55%

See 1 more Smart Citation

Sesquiterpenes evaluation on Schistosoma mansoni : Survival, excretory system and membrane integrity

Oliveira

Rodrigues-dos-Santos

Mendes

et al. 2017

Biomedicine & Pharmacotherapy

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 55%

“…3 G-H). The probes diffusion across the parasites tegument, further indicates that the treatments changed the schistosomes membrane integrity since the probe only enters the cell when there are lesions [34].…”

Section: Discussionmentioning

confidence: 98%

Sesquiterpenes evaluation on Schistosoma mansoni : Survival, excretory system and membrane integrity

Oliveira

Rodrigues-dos-Santos

Mendes

et al. 2017

Biomedicine & Pharmacotherapy

View full text Add to dashboard Cite

“…Michaels and Prata (1968) have followed egg maturation in two distinct culture media and defined the M199 containing 10% calf serum as more adequate to support egg embryogenesis and miracidial life span as well as the host environment. However, other authors prefer the RPMI-1640 culture medium (Ashton et al 2001;Kusel et al 2006;Schramm et al 2006). We have evaluated here the embryonic development of S. mansoni eggs in this medium and compared it with data obtained from isolated eggs.…”

Section: Discussionmentioning

confidence: 99%

“…Adult worms were recovered by direct incisions of the portal hepatic intestinal system or as described by Kusel et al (2006). Miracidia were obtained from blended livers by using a modified hatching method as described previously (Jurberg et al 2008a).…”

Section: Parasitesmentioning

confidence: 99%

The embryonic development of Schistosoma mansoni eggs: proposal for a new staging system

et al. 2009

View full text Add to dashboard Cite

Schistosomiasis is a water-borne parasitic illness caused by neoophoran trematodes of the genus Schistosoma. Using classical histological techniques and whole-mount preparations, the present work describes the embryonic development of Schistosoma mansoni eggs in the murine host and compares it with eggs maintained under in vitro conditions. Two pre-embryonic stages occur inside the female worm: the prezygotic stage is characterized by the release of mature oocytes from the female ovary until its fertilization. The zygotic stage encompasses the migration of the zygote through the ootype, where the eggshell is formed, to the uterus. Fully formed eggs are laid still undeveloped, without having suffered any cleavage. In the outside environment, eight embryonic stages can be defined: stage 1 refers to early cleavages and the beginning of yolk fusion. Stage 2 represents late cleavage, with the formation of a stereoblastula and the onset of outer envelope differentiation. Stage 3 is defined by the elongation of the embryonic primordium and the onset of inner envelope formation. At stage 4, the first organ primordia arise. During stages 5 to 7, tissue and organ differentiation occurs (neural mass, epidermis, terebratorium, musculature, and miracidial glands). Stage 7 is characterized by the nuclear condensation of neurons of the central neural mass. Stage 8 refers to the fully formed larva, presenting muscular contraction, cilia, and flame-cell beating. This staging system was compared to a previous classification and could underlie further studies on egg histoproteomics (morphological localizome). The differentiation of embryonic structures and their probable roles in granulomatogenesis are discussed herein.

show abstract

“…Praziquantel also inhibits the excretory system of worms (Kusel et al 2006) and induces a rapid hepatic shift (5 min to an hour after administration) of schistosome worms from the mesenteric plexuses to the liver (Mehlhorn et al 1981), and that was presumed to be due to the increased muscular contraction following the rapid uptake of the drug by the worms (Jeziorski and Greenberg 2006). The absolute oral bioavailability of the drug is unknown.…”

Section: Mechanism Of Actionmentioning

confidence: 99%

Current chemotherapy arsenal for schistosomiasis mansoni: alternatives and challenges

et al. 2009

View full text Add to dashboard Cite

Schistosomiasis still represents a major health problem in many tropical and subtropical countries despite continuing control efforts. Due to the unavailability of a vaccine that is practically applicable to humans, the use of chemotherapy is the mainstay of schistosomiasis-associated morbidity control. This paper attempts to review the antischistosomal drugs currently used in the treatment of intestinal schistosomiasis caused by Schistosoma mansoni. Their antischistosomal properties, advantages, and disadvantages as well as issues regarding the evidence for drug resistance and combination studies are reviewed in a simple manner. The recent trends towards the identification of specific chemotherapeutic targets for the treatment of schistosomes are also discussed briefly.

show abstract

The effects of drugs, ions, and poly-l-lysine on the excretory system of Schistosoma mansoni

Cited by 23 publications

References 19 publications

Sesquiterpenes evaluation on Schistosoma mansoni : Survival, excretory system and membrane integrity

Sesquiterpenes evaluation on Schistosoma mansoni : Survival, excretory system and membrane integrity

The embryonic development of Schistosoma mansoni eggs: proposal for a new staging system

Current chemotherapy arsenal for schistosomiasis mansoni: alternatives and challenges

Contact Info

Product

Resources

About