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Cited by 18 publications
(17 citation statements)
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References 21 publications
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“…Drug‐induced gametocytogenesis has been observed before with pyrimethamine use in P. chabaudi in vivo (Buckling et al 1999a) and in P. falciparum following chloroquine treatment in vitro (Buckling et al 1999b). Many authors have reported gametocytogenesis following SP drug treatment of human falciparum infections (Puta and Manyando 1997; Robert et al 2000; Osorio et al 2002; Sowunmi and Fateye 2003; Talman et al 2004; Ali et al 2006; Sowunmi et al 2006), although field data are difficult to interpret in the absence of untreated controls. It has been proposed that drug‐induced gametocytogenesis is a facultative response to conditions unfavorable to in‐host replication (Buckling et al 1997), and our data are consistent with that.…”
Section: Discussionmentioning
confidence: 99%
“…Drug‐induced gametocytogenesis has been observed before with pyrimethamine use in P. chabaudi in vivo (Buckling et al 1999a) and in P. falciparum following chloroquine treatment in vitro (Buckling et al 1999b). Many authors have reported gametocytogenesis following SP drug treatment of human falciparum infections (Puta and Manyando 1997; Robert et al 2000; Osorio et al 2002; Sowunmi and Fateye 2003; Talman et al 2004; Ali et al 2006; Sowunmi et al 2006), although field data are difficult to interpret in the absence of untreated controls. It has been proposed that drug‐induced gametocytogenesis is a facultative response to conditions unfavorable to in‐host replication (Buckling et al 1997), and our data are consistent with that.…”
Section: Discussionmentioning
confidence: 99%
“…In spite of significantly faster parasite clearance in the ALtreated children, gametocyte carriage after treatment was similar to that in those treated with ASP. This outcome was unexpected for a number of reasons, e.g., slower clearance of parasitemia is associated with an increased risk of gametocyte carriage; [35][36][37] and pyrimethamine-sulfalene, presumably similar to pyrimethamine-sulfadoxine and trimethoprimsulfamethoxazole, should enhance gametocyte release into the circulation, [36][37][38][39][40][41] but this effect of antifolates could have been modulated by their combination with amodiaquine. The latter is supported by the finding that combination of antifolates with other antimalarial drugs, e.g., 4-aminoquinolines 12,25,39,41 or artesunate, 42 results in reduced frequency of gametocyte carriage compared with the antifolates alone.…”
Section: Discussionmentioning
confidence: 99%
“…Resistance reversal agents would potentially reduce the large selection pressure that CQ would exert on parasite reservoirs with mutant pfcrt alleles. One such agent is the antihistamine chlorpheniramine, which has been demonstrated clinically to ameliorate CQ efficacy130. Indeed, a recent study found comparable mean fever clearance times between groups treated with CQ–chlorpheniramine or amodiaquine partnered with sulphadoxine–pyrimethamine (AQ–SP).…”
Section: Further Issues For Act Implementationmentioning
confidence: 99%