2006
DOI: 10.1590/s0074-02762006000400004
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Abstract: The pathogenesis of Schistosoma mansoni infection is largely determined by host T-cell mediated immuneSchistosomiasis is a debilitating parasitic disease affecting about 200 million people in 70 countries in the world and is caused by one of the three different species of Schistosoma: S. mansoni, S. haematobium, and S. japonicum. The major pathology of these parasitic infections is associated with a host delayed type hypersensitivity reaction to parasitic egg and egg products. Granulomatous inflammation is a c… Show more

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Cited by 30 publications
(25 citation statements)
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“…Homologues of MIF have been identified in a number of parasites including the malaria parasite Plasmodium falciparum [46] and are thought to play a role in manipulation of the host immune response to enhance parasite survival in a number of species of helminth parasites. A homologue of a schistosome major egg antigen was also identified and this may prove to be of interest as egg development factors represent potential therapeutic targets [47]. Other factors found included four ESTs involved in spermatogenesis and sperm motility, these factors could form future targets for chemical/therapeutic control of sheep scab as disease pathogenesis relies upon successive rounds of mite reproduction [7].…”
Section: Resultsmentioning
confidence: 99%
“…Homologues of MIF have been identified in a number of parasites including the malaria parasite Plasmodium falciparum [46] and are thought to play a role in manipulation of the host immune response to enhance parasite survival in a number of species of helminth parasites. A homologue of a schistosome major egg antigen was also identified and this may prove to be of interest as egg development factors represent potential therapeutic targets [47]. Other factors found included four ESTs involved in spermatogenesis and sperm motility, these factors could form future targets for chemical/therapeutic control of sheep scab as disease pathogenesis relies upon successive rounds of mite reproduction [7].…”
Section: Resultsmentioning
confidence: 99%
“…For example, HSP40 (major egg antigen) has been proposed as an ‘anti-pathology’ schistosomal vaccine candidate due to its ability to stimulate IL-5 and IL-10 but not IL-4 and IL-13. Such a cytokine profile is associated with reduced collagen deposition, decreased fibrosis and granuloma inhibition formation which are hallmarks of the ultimately destructive host immune response against schistosome eggs [82]. Shalaby and colleagues [83] were able to achieve significant reductions in worm burden by DNA vaccination against enzymes such as superoxide dismutase and glutathione peroxidase.…”
Section: Resultsmentioning
confidence: 99%
“…P40, a 40-kDa peptide, is a major component of schistosome eggs, named as SmP40 in Schistosoma mansoni (S.mansoni) or SjP40 in S. japonicum (Liu et al 2006;Zhou et al 2010). SmP40 likely revealed the anti-pathology action in schistosomiasis, since stimulation with SmP40 in PBMC resulted in decreased IL-5 expression and increased IL-10 expression, both of these effects were associated with reduced fibrosis (Abouel-Nour et al 2006). However, these findings have not established whether P40 could inhibit the activation of HSCs directly.…”
Section: Discussionmentioning
confidence: 99%