Selective suppression of leukocyte recruitment in allergic inflammation

Requirement of L-selectin for γδ T lymphocyte activation and migration during allergic pleurisy: Co-relation with eosinophil accumulation

“…CCL11, IL-5 and IL-4 are important mediators involved in the pathogenesis of allergic reactions, as in eosinophil accumulation in inflamed tissue [31]. Therefore, it was further analyzed if fucoidan impairment of γδ T cell activation and migration into the pleural cavity of OVA-challenged mice could alter local production of such mediators.…”

Aqueous extract of Bowdichia virgilioides stem bark inhibition of allergic inflammation in mice

“…Considering the recognized effect of pro-inflammatory mediators, such as IL-5 and CCL11, on the recruitment of eosinophils on inflammatory tissue after allergen challenge (Weller et al, 2005), we decided to evaluate whether oral treatment with AEBv could influence the generation of these mediators in cells from inflammatory infiltrate after allergen challenge. Our results show that IL-5 and CCL11 mRNA expression were increased by leukocytes 24 h after OVA challenge, suggesting that inflammatory cells might contribute to changes in IL-5 and CCL11 levels at the inflammatory site.…”

The anti-allergic activity of the acetate fraction of Schinus terebinthifolius leaves in IgE induced mice paw edema and pleurisy

“…Among the C-C chemokines, CCL11/eotaxin, in addition to IL-5, diffuses into the circulation and acts synergistically to induce eosinophil release from the bone marrow into the blood. CCL5/RANTES, some of the monocyte chemoattract proteins (MCPs) and MIP-1α are other CC chemokines that are also known to stimulate eosinophil responses [39][40][41]. Based on that, we examined the leukocyte influx into the pleura cavity, and our results show that the treatment with the ST fraction inhibited eosinophil accumulation in allergic pleurisy without a significant change in mononuclear cell or neutrophil recruitment.…”