Vaccination with antioxidant enzymes confers protective immunity against challenge infection with Schistosoma mansoni

LoVerde, Philip T.; Carvalho-Queiroz, Claudia; Cook, Rosemary

doi:10.1590/s0074-02762004000900007

Cited by 47 publications

(25 citation statements)

References 42 publications

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“…Both forms are more represented in the adult worm; in the tegument and in the intestinal epithelium of the adult stage, the cytosolic and extracellular enzymes are present, whereas the latter is localised also in the membranes of parenchymatous cells and cellular organelles (Hong et al 1992;Mei and LoVerde 1997). Recent studies have shown that the cytosolic SOD of S. mansoni might represent a candidate vaccine against this parasite, giving around 39% of protection in immunised mice (LoVerde et al 2004). Schistosoma lacks catalase, but a low activity of GPx is present mainly in the tegument of the adult stages (Mkoji et al 1988;Mei and LoVerde 1997).…”

Section: S Mansonimentioning

confidence: 99%

Enzymatic antioxidant systems in helminth parasites

Chiumiento

Bruschi

2009

Parasitol Res

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Section: S Mansonimentioning

confidence: 99%

Enzymatic antioxidant systems in helminth parasites

Chiumiento

Bruschi

2009

Parasitol Res

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“…And due to this activity, many research works have been carried out as a target for drugs to protect the host against the pathogens like Plasmodium falciparum [14], Brucella abortus, Schistosoma mansoni [15] and antigenic agent in serodiagnosis [16]. It has shown to increase the efficiency of penetration through skin from topical creams, when fused with HIV-1 tat protein transduction domain or lysine-rich peptide [17].…”

Section: Industrial Applications Of Sodmentioning

confidence: 99%

Industrial Production of Superoxide Dismutase (SOD): A Mini Review

Gopal¹,

Elumalai²

2017

J Prob Health

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The use of chemical advances to mechanical research, improvement, and assembling has turned into a critical field. Since the creation of rough rennet in 1874, a few catalysts have been marketed, and utilized for restorative, supplementary, and different applications. Late headways in biotechnology now enable organizations to create more secure and more affordable chemicals with upgraded intensity and specificity. Cancer prevention agent catalysts are developing as another expansion to the pool of modern chemicals and are outperforming every single other compound as far as the volume of research and creation. In the 1990s, a cell reinforcement chemical-superoxide dismutase (SOD) was brought into the market. In spite of the fact that the catalyst at first demonstrated extraordinary guarantee in restorative applications, it didn't perform up to desires. Therefore, its utilization was restricted to nontranquilize applications in people and medication applications in creatures. This survey compresses the ascent and fall of SOD at the mechanical level, the purposes behind this, and potential future push territories that should be tended to. The audit likewise concentrates on other modernly significant parts of SOD, for example, mechanical significance, catalyst designing, generation procedures, and process streamlining and scale-up.

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“…Treatment of inflammation in animals [86,93] Clinical purposes and specific applications in the food industry systems [3,58,66,67,70,85,87,93,94] Preservation of perishables like vegetables [88] Preservation of biologicals, like organs for transplantation and sperms [89,90] Reduction in tobacco and alcohol-induced damage [91] Biosensor for O2 − [92] Cosmetics for the protection of the skin [3,30] Prevent alcohol-induced hangover [95] Removal of Amadori and Maillard products [96] Mutagenicity testing [97,98] elicited these effects by scavenging the inflammatory superoxide anion [73]. Elevated SOD activity can be therapeutically useful by protecting against oxidative stress-induced neurotoxicity.…”

Section: Applications Referencementioning

confidence: 99%

“…Similarly, ROS-generating chemicals are used as food preservatives to prevent microbial growth [84]. In pathogens, SOD performs a very important role in the dismutation of extracellular ROS derived from oxidative burst of phagocytes (Table 6) [85].…”

Section: Applications Referencementioning

confidence: 99%