2004
DOI: 10.1590/s0074-02762004000900005
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Abstract: Chronic Schistosoma mansoni infection leads to a type 2-immune response with increased production of interleukin

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Cited by 59 publications
(52 citation statements)
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References 49 publications
(52 reference statements)
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“…Furthermore, there is evidence that chronic exposure to S. mansoni not only downregulated Th1 responses and prevented the onset of Th1-mediated diseases, e.g. MS, diabetes mellitus, and Crohn's disease, but also down-regulated atopic diseases including some Th2-mediated diseases [15]. The mechanism of suppression associated with chronic schistosomiasis suggested that the establishment of Treg, which favor parasite survival, also diminishes the severity of immune-mediated pathology and may contribute to diminishing manifestations of atopic disease [16,17].…”
Section: Introductionmentioning
confidence: 99%
“…Furthermore, there is evidence that chronic exposure to S. mansoni not only downregulated Th1 responses and prevented the onset of Th1-mediated diseases, e.g. MS, diabetes mellitus, and Crohn's disease, but also down-regulated atopic diseases including some Th2-mediated diseases [15]. The mechanism of suppression associated with chronic schistosomiasis suggested that the establishment of Treg, which favor parasite survival, also diminishes the severity of immune-mediated pathology and may contribute to diminishing manifestations of atopic disease [16,17].…”
Section: Introductionmentioning
confidence: 99%
“…Epidemiologic studies examining the influence of helminth infection on allergic disease have demonstrated an inverse relationship between the longevity and magnitude of parasite infection and the development of the allergic response (3,31). For example, asthmatic patients infected with Schistosoma mansoni were shown to have lower levels of the proallergic cytokines interleukin-4 (IL-4) and IL-5 than their noninfected counterparts when challenged with house dust mite antigen (4).…”
mentioning
confidence: 99%
“…It is suggested that the adoption of hygienic lifestyles in these countries have contributed to a decline in helminths or parasitic worm infections (166). Epidemiological studies (167)(168)(169) have suggested that helminths may provide protection against some immune-mediated diseases and the eradication may in fact promote these diseases. Animal studies have shown helminth protection by promoting regulatory immune responses.…”
Section: Helminthsmentioning
confidence: 99%