2004
DOI: 10.1590/s0074-02762004000700017
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Abstract: The antileishmanial activity of lapachol, isolapachol, and dihydrolapachol, along

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Cited by 73 publications
(35 citation statements)
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References 36 publications
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“…Many studies have demonstrated the effect of lapachol against leishmaniosis (Lima et al, 2004), Chagas disease (Carvalho et al, 1988;Grazziotin et al, 1992;Santos et al, 2001;Silva et al, 2009), and schistosomiasis (Lima et al, 2002). Ravelo et al (2004) suggested that lapachol has potential for preventing cancer.…”
Section: Resultsmentioning
confidence: 99%
“…Many studies have demonstrated the effect of lapachol against leishmaniosis (Lima et al, 2004), Chagas disease (Carvalho et al, 1988;Grazziotin et al, 1992;Santos et al, 2001;Silva et al, 2009), and schistosomiasis (Lima et al, 2002). Ravelo et al (2004) suggested that lapachol has potential for preventing cancer.…”
Section: Resultsmentioning
confidence: 99%
“…Because of its antiproliferative activity, lapachol has been employed as a prototype for the design and synthesis of new anticancer and antimicrobial agents. This has led to the identification of fewer lapachol derivatives with an enhanced activity [9][10][11][12].…”
Section: Introductionmentioning
confidence: 99%
“…Apart from plumbagin, lapachol (Q4) was found to be the most toxic to M. avium as previously determined with other assays [51]. Interestingly, lapachol and similar quinones have recently been shown to exhibit strong inhibitory properties against two species of Leishmania associated to tegumentar leishmaniasis [52]. Although lapachol was found unsuitable as an anticancer drug due to its toxic side effects [53], it has recently been shown to exhibit anti-metastatic effects by inhibiting the invasiveness of cancer cells [54].…”
Section: 7 Large-scale Screening Of Compounds On Eukaryotic and Prsupporting
confidence: 60%