Antimicrobial activity and chemical investigation of Brazilian Drosera

Ferreira, Dalva Trevisan; Andrei, Cesar C.; Saridakis, Halha Ostrensky; Faria, Terezinha de Jesus; Vinhato, Elisângela; Carvalho, Kátia Eliane; Daniel, Juliana F. S.; Machado, Silvio Luiz; Saridakis, Dennis Panayotis; Braz-Filho, Raimundo

doi:10.1590/s0074-02762004000700016

Cited by 18 publications

(8 citation statements)

References 5 publications

(6 reference statements)

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“…Drosera species are known to contain flavonoids, naphthoquinones, ellagic acid and other polyphenols (Krenn et al, 1998;Ferreira et al, 2004;Paper et al, 2005). Paper et al (2005) demonstrated that 70% ethanol extracts of Drosera rotundifolia and Drosera madagascariensis contained negligible amounts of naphthoquinones, and high amounts of ellagic acid and certain flavonoids.…”

Section: Discussionmentioning

confidence: 99%

Drosera rotundifolia and Drosera tokaiensis suppress the activation of HMC-1 human mast cells

Fukushima

Nagai

Hoshi

et al. 2009

Journal of Ethnopharmacology

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Section: Discussionmentioning

confidence: 99%

Drosera rotundifolia and Drosera tokaiensis suppress the activation of HMC-1 human mast cells

Fukushima

Nagai

Hoshi

et al. 2009

Journal of Ethnopharmacology

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“…Plumbagin has been shown to have toxicity against several pathogenic and non-pathogenic microbes [21][22][23]. For example, it has been shown to inhibit the proliferation of various bacteria such as Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus subtilis, Proteus vulgaris, Mycobacterium smegmatis mc 2 155 and Mycobacterium tuberculosis H37Rv [22,23].…”

Section: Introductionmentioning

confidence: 99%

“…Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) is a secondary plant metabolite exhibiting several biological activities, including its ability to inhibit proliferation of mammalian, fungal and bacterial cells [16][17][18][19][20]. Plumbagin has been shown to have toxicity against several pathogenic and non-pathogenic microbes [21][22][23]. For example, it has been shown to inhibit the proliferation of various bacteria such as Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus subtilis, Proteus vulgaris, Mycobacterium smegmatis mc 2 155 and Mycobacterium tuberculosis H37Rv [22,23].…”

Section: Introductionmentioning

confidence: 99%

Plumbagin inhibits cytokinesis in Bacillus subtilis by inhibiting FtsZ assembly – a mechanistic study of its antibacterial activity

et al. 2013

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The assembly of FtsZ plays a central role in construction of the cytokinetic Z-ring that orchestrates bacterial cell division. A naturally occurring naphthoquinone, plumbagin, is known to exhibit antibacterial properties against several types of bacteria. In this study, plumbagin was found to perturb formation of the Z-ring in Bacillus subtilis 168 cells and to cause elongation of these cells without an apparent effect on nucleoid segregation, indicating that it may inhibit FtsZ assembly. Furthermore, it bound to purified B. subtilis FtsZ (BsFtsZ) with a dissociation constant of 20.7 AE 5.6 lM, and inhibited the assembly and GTPase activity of BsFtsZ in vitro. Interestingly, plumbagin did not inhibit either the assembly or GTPase activity of Escherichia coli FtsZ (EcFtsZ) in vitro. Using docking analysis, a putative plumbagin-binding site on BsFtsZ was identified, and the analysis indicated that hydrophobic interactions and hydrogen bonds predominate. Based on the in silico analysis, two variants of BsFtsZ, namely D199A and V307R, were constructed to explore the binding interaction of plumbagin and BsFtsZ. The effects of plumbagin on the assembly and GTPase activity of the variant BsFtsZ proteins in vitro indicated that the residues D199 and V307 may be involved in the binding of plumbagin to BsFtsZ. The results suggest that plumbagin inhibits bacterial proliferation by inhibiting the assembly of FtsZ, and provide insight into the binding site of plumbagin on BsFtsZ, which may help in the design of potent FtsZ-targeted antibacterial agents.

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“…This extract was active against all the bacterial species tested (MBC = 25-75 mg fresh weight/ml). Ferreira et al (2004) (Crouch et al, 1990). The reason for this phenomenon is unknown and may be caused by a missing environmental factor.…”

Section: Naphthoquinonesmentioning

confidence: 99%

In vitro cultures of carnivorous plants from the Drosera and Dionaea genus for the production of biologically active secondary metabolites

Banasiuk¹,

Kawiak²,

Królicka³

2012

bta

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Carnivorous plants belong to endangered species. Due to agricultural development, natural populations of these plants are diminishing. The herbal and ornamental value of these species has also led to their over-collection.The Drosera genus is a natural source of pharmacologically important compounds (e.g. naphthoquinones, flavonoids, anthocyanins, phenolic compounds) used as substrates in the production of pharmaceuticals. Droserae herba has been in use as an expectorant, diuretic and antispasmodic agent. In recent years, the bacteriostatic and antitumour activity of Drosera extracts has been reported. Carnivorous plants have become an important ornamental element in botanical garden collections. This fact, as well as the low propagation rate in their natural environment, is the reason for the in vitro propagation of carnivorous plants. From a single plant cultivated in vitro many genetically identical clonal lines can be obtained through vegetative propagation. This technique allows for the increase in the propagation rate of valuable plant material. Additionally, the use of biotic and abiotic elicitors increases the synthesis of pharmacologically active compounds (bactericidal, bacteriostatic activity and cytotoxic activity). Elicitors play a significant role in the production of secondary metabolites. They induce defense responses in plants, which leads to the accumulation of secondary metabolites. In some cases, compounds not synthesized normally by plants in their natural environment are produced upon elicitation. Elicitors induce the biosynthesis of enzymes which take part in the production of secondary metabolites.

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Antimicrobial activity and chemical investigation of Brazilian Drosera

Abstract: The antimicrobial activity of three different extracts (hexanic, ethyl acetate, methanol)

Cited by 18 publications

References 5 publications

Drosera rotundifolia and Drosera tokaiensis suppress the activation of HMC-1 human mast cells

Drosera rotundifolia and Drosera tokaiensis suppress the activation of HMC-1 human mast cells

Plumbagin inhibits cytokinesis in Bacillus subtilis by inhibiting FtsZ assembly – a mechanistic study of its antibacterial activity

In vitro cultures of carnivorous plants from the Drosera and Dionaea genus for the production of biologically active secondary metabolites

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