Infection of Calomys callosus (Rodentia Cricetidae) with strains of different Trypanosoma cruzi biodemes: pathogenicity, histotropism, and fibrosis induction

Magalhães-Santos, Isis Fernandes; Souza, Márcia María de; Lima, Carolina Silva Costa; Andrade, Sônia Gumes

doi:10.1590/s0074-02762004000400011

Cited by 16 publications

(8 citation statements)

References 13 publications

(7 reference statements)

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“…Indeed, binding between extracellular matrix proteins and T. cruzi receptors has been described as a significant step in this phenomenon (Santana et al ., 1997). It is important to report that Magalhães‐Santos et al (2004), working with Calomys callosus , did not observe an increase of collagen deposits in damaged tissues.…”

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confidence: 95%

Trypanosoma cruziand myoid cells from seminiferous tubules: interaction and relation with fibrous components of extracellular matrix in experimental Chagas’ disease

Carvalho

Abreu-Silva

Hardoim

et al. 2009

Int J Experimental Path

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The main transmission route of Trypanosoma cruzi is by triatomine bugs. However, T. cruzi is also transmitted through blood transfusion, organ transplantation, ingestion of contaminated food or fluids, or is congenital. Sexual transmission, although suggested since the discovery of Chagas' disease, has remained unproven. Sexual transmission would require T. cruzi to be located at the testes and ovaries. Here we investigated whether T. cruzi is present in the gonads of mice infected with 10(4) T. cruzi trypomastigotes from the CL strain. Fourteen days after experimental infection, histopathological examination showed alterations in the extracellular matrix of the lamina propria of the seminiferous tubules. Furthermore, amastigotes were present in seminiferous tubules, within myoid cells, and in the adjacencies of the basal compartment. These results indicate that T. cruzi is able to reach seminiferous tubule lumen, thus suggesting that Chagas' disease could potentially be transmitted through sexual intercourse. Complementary studies are required to demonstrate that Chagas' disease can be transmitted by coitus.

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confidence: 95%

Trypanosoma cruziand myoid cells from seminiferous tubules: interaction and relation with fibrous components of extracellular matrix in experimental Chagas’ disease

Carvalho

Abreu-Silva

Hardoim

et al. 2009

Int J Experimental Path

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“…It involves parasitized macrophages, cardiac and skeletal muscles cells in different animal species such as mice, dogs, and Callomys callosus (Andrade 1991, Cordeiro et al 1997, Magalhães-Santos et al 2004. In acute Chagas' disease in humans, necrosis of cardiac myocells, either containing intracellular forms of T. cruzi or in the absence of parasites, constitutes an outstanding feature in advanced acute chagasic myocarditis (Andrade 1991).…”

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confidence: 99%

Importance of TNF-alpha in the course of acute infection with Trypanosoma cruzi: influence of its inhibition by pentoxifylline treatment

Andrade

Magalhães

Pessina

2008

Mem. Inst. Oswaldo Cruz

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“…The various clinical manifestations that occur throughout the development of Chagas’ disease are directly related to the genotype of the circulating parasites, the geographic origin and the cycles of wild and domestic transmission. This is because these variations in the populations determine the tropism to the tissues, the parasitaemia, and the pathogenesis in the vertebrate hosts during the acute and chronic phase of the disease (Andrade et al ., 1999; Macedo et al ., 2004; Magalhães-Santos et al ., 2004). In our review, we observed that, after 50 inoculations with more than 20 different T. cruzi strains, those belonging to the TcI (ex Colombian), TcII (ex Y) (Galea et al , 2007) and TcIV (ex AM05) (Meza et al ., 2014) were those that presented histotropism for the CNS.…”

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confidence: 99%

Infection byTrypanosoma cruziin the central nervous system in non-human mammals: a systematic review

et al. 2019

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Currently, the types and distribution of the lesions induced in the central nervous system (CNS) by Trypanosoma cruzi remain unclear as the available evidence is based on fragmented data. Therefore, we developed a systematic review to analyse the main characteristics of the CNS lesions in non-human hosts infected. From a structured search on the PubMed/Medline and Scopus platforms, 32 studies were retrieved, subjected to data extraction and methodological bias analysis. Our results show that the most frequent alterations in the CNS are the presence of different forms of T. cruzi and intense lymphocytes infiltrates. The encephalon is the main target of T. cruzi, and inflammatory changes in the CNS are more frequent and severe in the acute phase of infection. The parasite's genotype and phenotype are associated with the tropism and severity of the CNS lesions. The methodological limitations found in the studies were divergences in inoculation pathways, under-reporting of animal age and weight, sample calculation strategies and histopathological characterization. Since the changes were dependent on the pathogenicity and virulence of the T. cruzi strains, the genotype and phenotype characterization of the parasite are extremely relevant to predict changes in the CNS and the neurological manifestations associated with Chagas’ disease.

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Infection of Calomys callosus (Rodentia Cricetidae) with strains of different Trypanosoma cruzi biodemes: pathogenicity, histotropism, and fibrosis induction

Abstract: The influence of different Trypanosoma cruzi biodemes on the evolution of the infection and on the histopathological lesions of the heart and skeletal muscles, during the experimental infection of

Cited by 16 publications

References 13 publications

Trypanosoma cruziand myoid cells from seminiferous tubules: interaction and relation with fibrous components of extracellular matrix in experimental Chagas’ disease

Trypanosoma cruziand myoid cells from seminiferous tubules: interaction and relation with fibrous components of extracellular matrix in experimental Chagas’ disease

Importance of TNF-alpha in the course of acute infection with Trypanosoma cruzi: influence of its inhibition by pentoxifylline treatment

Infection byTrypanosoma cruziin the central nervous system in non-human mammals: a systematic review

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