Prevalence of human papillomavirus type 16 variants in the Federal District, Central Brazil

Cruz, Márcio Rojas da; Cerqueira, Daniela Marreco; Cruz, Waldenor B.; Camara, Geni N. L.; Brigido, Marcelo M.; Silva, Evandro O.; Carvalho, Luciano G. S.; Martins, Cláudio

doi:10.1590/s0074-02762004000300007

Cited by 18 publications

(16 citation statements)

References 13 publications

(7 reference statements)

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“…Exact logistic regression analysis adjusting for age revealed a trend towards increased prevalence of Asian-American variants in HIV-positive women compared with HIV-negative women (exact p ϭ 0.097) and significantly higher prevalence of variants with a mutation at nt 350 in HIV-positive women (exact p ϭ 0.026) This is the first study in Brazil to evaluate HPV16 variants among HIV-negative and -positive women. In this series, although we did not observe an increased oncogenic potential for the Asian-American variants of HPV16, other studies (2,9,30); conducted in the Americas showed conflicting results. Berumen et al (2) reported that HPV16 Asian-American variants are able to confer a higher risk for cervical cancer than HPV16 European variants and also that almost a quarter of all cervical cancers in Mexico can be attributed to Asian-American variants.…”

Section: Gheit Et Alcontrasting

confidence: 85%

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HPV16 Variants in Squamous Intraepithelial Lesions in Human Immunodeficiency Virus–Negative and –Positive Brazilian Women

Gheit

Simões²,

Tommasino³

et al. 2006

Viral Immunology

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Emerging evidence supports the role of human papillomavirus (HPV) intratype variations in the development of cervical lesions in immunocompetent women, but few studies investigated HPV16 variants in human immunodeficiency virus (HIV)-positive women. This is the first study in Brazil evaluating HPV16 variants in women with (n = 19) and without (n = 22) HIV infection, as well as cervical lesions. Although non-European variants presented an almost 3-fold increase (13.6% vs. 36.8%) among HIV-positive women, associations between HPV16 variants and HIV infection did not reach statistical significance (Fisher's exact test, p = 0.15). No associations were found between non-European variants and HSIL (Fisher's exact test, p = 0.41), although a significant association was observed between European variants and HSIL among HIV-negative women (Fisher's exact test, p = 0.01). In conclusion, in HIV-negative women the HPV16 European variants seem to influence the occurrence of HSIL, whereas in HIV-positive women, similar roles are atributted to both variants.

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Section: Gheit Et Alcontrasting

confidence: 85%

“…However, these findings have not been confirmed in other studies (4,14). In Brazil, the predominant variants are European, followed by AsianAmerican with Q14H, H78Y, and L83V simultaneous mutations (9,30). Interestingly, regional differences in the prevalence of HPV16 variants may also be associated with host immune responses (12).…”

Section: Introductionmentioning

confidence: 83%

HPV16 Variants in Squamous Intraepithelial Lesions in Human Immunodeficiency Virus–Negative and –Positive Brazilian Women

Gheit

Simões²,

Tommasino³

et al. 2006

Viral Immunology

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“…This was also found in southeastern (Villa et al, 2000) and central Brazil (Cruz et al, 2004;Alencar et al, 2007). Variants of HPV type 16 are typically classified into European, African, Asian-American, and North-American, or Amerindian (Yamada et al, 1997).…”

Section: Prevalence Of the Types Of Hpvmentioning

confidence: 88%

“…Cervical cancer is the most common disease in Brazilian women, and infection by HPV is the main risk factor for development of this pathology. In Brazil, most studies of HPV were conducted in southeastern (Villa et al, 2000) or in central regions of the country (Cruz et al, 2004;Alencar et al, 2007;Cerqueira et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Prevalence of human papillomavirus (HPV) type 16 variants and rare HPV types in the central Amazon region

Castro¹,

Farias²,

Borborema-Santos³

et al. 2011

Genet. Mol. Res.

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ABSTRACT. Infection by human papillomavirus (HPV) is one of the primary causes of mortality by cancer in northern Brazil. Sexually active women from Manaus, Amazonas, without cytological alterations and women with pre-malignant and malignant cytological alterations were examined for HPV virus, identified via PCR and sequencing. The target region for this study was part of the L1 capsid gene of HPV. Twentythree samples that were PCR-positive were sequenced. Analysis of 336 bp demonstrated a high incidence of high-risk HPV types in the population of Manaus, identified as HPVs 16, 33, 58, 66, 68. HPV type 16 was the most prevalent, presenting two variants similar to the AsianAmerican (AA) and East-Asian type (As) variants. A rare HPV type 13 related to "Heck's disease" was also detected. This preliminary provides important information about the HPV circulating in Amazonas State.

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“…HPV-16 and -18 are associated with nearly 70% of cervical carcinomas worldwide, with HPV-18 being identified in approximately 20% of the high-risk infections [1]. The nucleotide variability of HPV-16 and -18 has been extensively studied, and several molecular variants have been described on the basis of their geographical distribution [2][3][4][5]. HPV-18 variants co-evolved with the three major phylogenetic human branches: Africans, Caucasians, and Asians, and were clustered into three distinct groups; European (E), Asian-American (AA), and African (Af) [6].…”

Section: Introductionmentioning

confidence: 99%

New variants of human papillomavirus type 18 identified in central Brazil

et al. 2008

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HPV-18 is the second most prevalent human papillomavirus genotype found in cervical cancer. Nucleotide variations in HPV-18 sequence can interfere with the viral oncogenic potential. However, the knowledge about HPV-18 variants in Brazil is still limited. The present study aims to determine the LCR, E6, and L1 genetic variability of HPV-18 variants found in women co-infected with HIV-1 in Central Brazil. Four HPV-18 samples were identified and had the LCR, E6, and L1 genomic regions sequenced. It was possible to characterize three European variants and one African variant of HPV-18. All of them are new variants, showing nucleotide substitutions not previously reported. Nucleotide variations in binding sites for transcriptional factors were observed. Phylogenetic analysis was also performed, evidencing the three clusters related to the Asian-American, African, and European variants. The characterization of HPV genetic variability is of pivotal importance to the understanding of the viral pathogenicity.

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Prevalence of human papillomavirus type 16 variants in the Federal District, Central Brazil

Abstract: We report the prevalence of human papillomavirus type

Cited by 18 publications

References 13 publications

HPV16 Variants in Squamous Intraepithelial Lesions in Human Immunodeficiency Virus–Negative and –Positive Brazilian Women

HPV16 Variants in Squamous Intraepithelial Lesions in Human Immunodeficiency Virus–Negative and –Positive Brazilian Women

Prevalence of human papillomavirus (HPV) type 16 variants and rare HPV types in the central Amazon region

New variants of human papillomavirus type 18 identified in central Brazil

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