Antimicrobial activity in vitro of plumbagin isolated from Plumbago species

Paiva, Selma Ribeiro de; Figueiredo, Maria Raquel; Aragão, Tânia Verônica; Kaplan, Maria Auxiliadora Coelho

doi:10.1590/s0074-02762003000700017

Cited by 144 publications

(86 citation statements)

References 9 publications

(3 reference statements)

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“…Bacillus subtilis is sensitive, whereas Escherichia coli is resistant to plumbagin (Bhattacharya et al, 2013;de Paiva et al, 2003). Previous proteomics analysis investigating the effect of plumbagin on E. coli showed upregulation of multiple proteins (mar/sox regulon) involved in detoxification of reactive oxygen species (Chen et al, 2006;Lin et al, 2010).…”

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confidence: 99%

Proteomics Analyses ofBacillus subtilisafter Treatment with Plumbagin, a Plant-Derived Naphthoquinone

Reddy

Sathe

et al. 2015

OMICS: A Journal of Integrative Biology

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Infectious diseases and increasing antibiotic resistance among diverse classes of microbes are global health concerns and a prime focus of omics systems science applications in novel drug discovery. Plumbagin is a plant-derived naphthoquinone, a natural product that exhibits antibacterial activity against gram-positive bacteria. In the present study, we investigated the antimicrobial effects of plumbagin against Bacillus subtilis using two complementary proteomics techniques: two-dimensional electrophoresis (2-DE) and isobaric tag for relative and absolute quantification (iTRAQ). Comparative quantitative proteomics analysis of plumbagin treated and untreated control samples identified differential expression of 230 proteins (1% FDR, 1.5 fold-change and ‡ 2 peptides) in B. subtilis after plumbagin treatment. Pathway analysis involving the differentially expressed proteins suggested that plumbagin effectively increases heme and protein biosynthesis, whereas fatty acid synthesis was significantly reduced. Gene expression and metabolic activity assays further corroborated the proteomics findings. We anticipate that plumbagin blocks the cell division by altering the membrane permeability required for energy generation. This is the first report, to the best of our knowledge, offering new insights, at proteome level, for the putative mode(s) of action of plumbagin and attendant cellular targets in B. subtilis. The findings also suggest new ways forward for the modern omics-guided drug target discovery, building on traditional plant medicine.

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confidence: 99%

Proteomics Analyses ofBacillus subtilisafter Treatment with Plumbagin, a Plant-Derived Naphthoquinone

Reddy

Sathe

et al. 2015

OMICS: A Journal of Integrative Biology

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“…Its root extract is widely used due to its medicinal property such as antibacterial [9], antifungal [10], antiparasitic [11,12], antifertility [13] s studies revealed the root extract against thioacetamideinduced oxidative stress [15]. However no comprehensive evidence has yet been documented for the experimentally.…”

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confidence: 99%

Curative effect of <em>Plumbago indica</em> root extract on thioacetamide induced hepatotoxicity in experimental rats

Eldhose¹,

Jayesh²,

Sankunni³

2017

ijpm

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A b s t r a c tThe root parts of The study was designed to evaluate the hepato curative activity Plumb methanolic root extracts at different doses (100 and 200 mg/kg bw) against thioacetamide induced liver damag Thioacetamide (100 mg/kg bw) and was assessed by evaluating the activity of liver marker enzymes, antioxidant enzymes and lipid peroxidation. The liver sections were evaluated serum liver enzymes and hepatic levels of antioxidant markers. Histopathological findings also confirmed the curative effect of scientifically rationale the use of liver disorders.

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“…Alguns trabalhos vêm demonstrando a atividade antimicrobiana de extratos etanólicos de plantas da flora nordestina. Pode-se citar a Amburana cearensis (BRAVO et al, 1999), Hymenaea courbaril, (NOGUEIRA et al, 2001), Borreria verticillata (PEIXOTO-NETO et al, 2002), Croton sonderianus (MCCHESNEY; CLARK; SILVEIRA, 1991), Hyptis suaveolens (IWU et al, 1990), Maytenus rigida (KLOUCEK et al, 2005), Pithecellobium cochliacarpum (ARAÚJO et al, 2002), Plumbago scandens (PAIVA et al, 2003), Ximenia americana (KONÉ et al, 2004), Guazuma ulmifolia (CACERES et al, 1993). A utilização dessa alternativa terapêutica por criadores e veterinários tem sido descrita, sendo os mesmos administrados aos animais em forma de soluções e pomadas para uso local ou administração de plantas verdes ou secas via oral (SCHUCH et al, 2008 …”

Section: Introductionunclassified

Potencial antimicrobiano de extratos etanólicos de plantas frente a bacilos gram negativos isolados da mucosa cérvico-vaginal de ovelhas criadas na região de Petrolina-PE

et al. 2014

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Potencial antimicrobiano de extratos etanólicos de plantas frente a bacilos gram negativos isolados da mucosa cérvico-vaginal de ovelhas criadas na região de Petrolina-PE AbstractReproductive tract infections are the main causes of losses from the low reproductive efficiency of sheep. Gram negative bacilli belonging to the normal flora of the genital region can trigger diseases. The pathogenicity of these agents is expressed when females are with weakened immune system, either by food or stress management. Flaws in and concern about antibiotic residues in animal production have prompted research regarding alternatives for the treatment of diseases. The herbal medicine has

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Antimicrobial activity in vitro of plumbagin isolated from Plumbago species

Abstract: Plumbagin is a naturally occurring naphthoquinone isolated from roots of

Cited by 144 publications

References 9 publications

Proteomics Analyses ofBacillus subtilisafter Treatment with Plumbagin, a Plant-Derived Naphthoquinone

Proteomics Analyses ofBacillus subtilisafter Treatment with Plumbagin, a Plant-Derived Naphthoquinone

Curative effect of <em>Plumbago indica</em> root extract on thioacetamide induced hepatotoxicity in experimental rats

Potencial antimicrobiano de extratos etanólicos de plantas frente a bacilos gram negativos isolados da mucosa cérvico-vaginal de ovelhas criadas na região de Petrolina-PE

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