Species distribution and antifungal susceptibility profile of Candida spp. bloodstream isolates from Latin American hospitals

Godoy, Patrício; Tiraboschi, Iris Nora; Severo, Luiz Carlos; Bustamante, Beatriz; Calvo, Belinda; Almeida, Leila Paula de; Matta, Daniel Archimedes da; Colombo, Arnaldo Lopes

doi:10.1590/s0074-02762003000300020

Cited by 72 publications

(55 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In this study, the majority of the diagnosed cases of fungemia had Candida species as the main agent, and such results are similar to the findings of other studies, suggesting this genus as primarily responsible for cases of fungemia in immunossupressed patients 2,15 .…”

Section: Discussionsupporting

confidence: 92%

Fungemia in a university hospital: an epidemiological approach

Couto

Macedo

Neves

2011

Rev. Soc. Bras. Med. Trop.

View full text Add to dashboard Cite

Introduction: Fungemia corresponds to the isolation of fungi in the bloodstream and occurs mostly in immunosuppressed patients. The early diagnosis and treatment of these infections are relevant given the serious threat to the affected patients and possible spread to other organs, often becoming fatal. The growing number of fungemia associated with poor prognosis resulted in this research aiming to diagnose and assess the epidemiological aspects of hematogenous infections by fungi. Methods: The study included 58 blood samples collected within a 1-year period, from patients at the Hospital das Clinicas, Federal University of Pernambuco, by venipuncture in vacuum tubes. Blood samples were processed for direct examination and culture and identification, conducted by observing the macroscopic and microscopic characteristics, as well as physiological characteristics when necessary. Results: Eight (13.8%) episodes of fungemia were identified, accounting for the total sample, and these pathogens were Candida, Histoplasma, Trichosporon, Cryptococcus, and a dematiaceous fungus. C. albicans was the prevalent species, accounting for 37.5% of the cases. Most affected patients were adult males. There was no predominance for any activity, and the risk of acquired immunodeficiency syndrome was the underlying pathology most often cited. Conclusions: The isolation of fungi considered as emergent species, such as C. membranifaciens and dematiaceous species, highlights the importance of epidemiological monitoring of cases of fungemia in immunocompromised patients, as the therapy of choice depends on the knowledge of the aethiological agent.

show abstract

Section: Discussionsupporting

confidence: 92%

Fungemia in a university hospital: an epidemiological approach

Couto

Macedo

Neves

2011

Rev. Soc. Bras. Med. Trop.

View full text Add to dashboard Cite

show abstract

“…In Latin American countries, especially Brazil, it is frequent even in non-cancer patients and constitutes the second or third most important cause of candidemia (26,37,38 amphotericin B and triazoles (101). This species has been recognized as the second main cause of invasive infection in Latin American countries (26,37,38).…”

Section: Colonization and Infection By Candida Sppmentioning

confidence: 99%

Oral Candida spp. colonization in human immunodeficiency virus-infected individuals

Moris¹,

Melhem²,

Martins³

et al. 2008

J. Venom. Anim. Toxins incl. Trop. Dis

View full text Add to dashboard Cite

“…Clinical isolates of this species are typically sensitive to amphotericin B and triazoles [13]; however, cases of resistance to these drugs, especially to fluconazole, have been recently reported and described [14].…”

Section: Introductionmentioning

confidence: 99%

Molecular Methods Developed for the Identification and Characterization of Candida Species

Grisolia¹

2017

IJGS

View full text Add to dashboard Cite

Candida species are commensally microorganisms in healthy individuals, but is also the most opportunistic fungal pathogen of human. From benign skin-mucosal forms to invasive ones, Candida infection, can compromise various organs systematic and cause diseases in immunocompromised or critically ill patients. Hence the accurate identification and characterization of the disease-causing strains is crucial for diagnosis, clinical treatment and epidemiological studies of candidacies. Molecular methods the identification and characterization support gives in epidemiological research and in development of novel antifungal with specific molecular targets, especially in the case of resistant Candida species. This review aims to describe the main methods used in the identification and characterization the Candida species and discusses future perspectives.

show abstract

Species distribution and antifungal susceptibility profile of Candida spp. bloodstream isolates from Latin American hospitals

Cited by 72 publications

References 27 publications

Fungemia in a university hospital: an epidemiological approach

Fungemia in a university hospital: an epidemiological approach

Oral Candida spp. colonization in human immunodeficiency virus-infected individuals

Molecular Methods Developed for the Identification and Characterization of Candida Species

Contact Info

Product

Resources

About