Hantavirus pulmonary syndrome in Uberaba, Minas Gerais, Brazil

Silva‐Vergara, Mario León; Júnior, José Carlos Costa; Barata, Cristina Hueb; Curi, Vítor Guilherme Maluf; Júnior, Carlos Giovanni Tiveron; Teixeira, Ana Cláudia

doi:10.1590/s0074-02762002000600005

Cited by 10 publications

(10 citation statements)

References 10 publications

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“…Fatal outcome occurred 1.3 Ϯ 0.5 days after admission to the hospital, and on the contrary, survivors stayed in the hospital for 8.9 Ϯ 4.5 days (53). Other studies describing the clinical presentations of HPS from other regions within the American Continent corroborate most of the clinical data presented here (27,90,295,366,400).…”

Section: Spectrum Of Hps Disease In the Americassupporting

confidence: 89%

A Global Perspective on Hantavirus Ecology, Epidemiology, and Disease

2010

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SUMMARY Hantaviruses are enzootic viruses that maintain persistent infections in their rodent hosts without apparent disease symptoms. The spillover of these viruses to humans can lead to one of two serious illnesses, hantavirus pulmonary syndrome and hemorrhagic fever with renal syndrome. In recent years, there has been an improved understanding of the epidemiology, pathogenesis, and natural history of these viruses following an increase in the number of outbreaks in the Americas. In this review, current concepts regarding the ecology of and disease associated with these serious human pathogens are presented. Priorities for future research suggest an integration of the ecology and evolution of these and other host-virus ecosystems through modeling and hypothesis-driven research with the risk of emergence, host switching/spillover, and disease transmission to humans.

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Section: Spectrum Of Hps Disease In the Americassupporting

confidence: 89%

A Global Perspective on Hantavirus Ecology, Epidemiology, and Disease

2010

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“…The prodromal phase is characterized by nonspecific clinical manifestations lasting from 3 to 6 days; the most common reported signs and symptoms in Brazilian patients are acute fever, chills, generalized myalgia, asthenia, headache and nausea; less often described are vomiting, abdominal pain, chest pain, sweating and dizziness [5,27,28].…”

Section: Hantavirus Pulmonary Syndrome In Brazilmentioning

confidence: 99%

“…During the prodromal phase, mild respiratory symptoms (dyspnea, tachypnea and dry cough) are frequently reported, as well as discrete basal rales at pulmonary auscultation [27,28]. Respiratory manifestations evolve into the cardiopulmonary phase worsening the respiratory distress with progressive dyspnea, which represents the most prominent symptom of this stage.…”

Section: Hantavirus Pulmonary Syndrome In Brazilmentioning

confidence: 99%

Twenty years of hantavirus pulmonary syndrome in Brazil: a review of epidemiological and clinical aspects

Pinto

Hamidad

Filho

et al. 2014

J Infect Dev Ctries

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Hantavirus infection is transmitted to humans by wild rodents and the most common clinical form in Brazil is the Hantavirus Pulmonary Syndrome (HPS). The first serological evidence of the disease was identified in 1990, in Recife, Pernambuco State, and later in 1993 in Juquitiba, State of São Paulo. Since then there has been a progressive increase in case notification in all regions of the country. The clinical aspects of the disease in Brazil are characterized by a prodromal phase, with nonspecific signs and symptoms of an acute febrile illness. After about three days, respiratory distress develops, accompanied by dry cough that turns progressively productive, evolving to dyspnea and respiratory failure with cardiogenic shock. Although the majority of patients receive hospital care in intensive care therapy units, case-fatality rate in Brazil ranges from 33% to 100% depending on the region. Besides it has to be added the problem of differential diagnosis with other prevalent diseases in the country, like dengue and leptospirosis. Questions about the impact of uncontrolled urbanization and other environmental changes caused by human action have been raised. Due to increasing incidence and high case-fatality, there is an urge to respond to such questions to recommend preventative measures. This article aims to review the main acquisitions in clinical and epidemiological knowledge about HPS in Brazil in the last twenty years.

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“…Thus, monitoring should be performed periodically in these regions. Between 1998, when the first case was reported in Minas Gerais, and August 2012, 108 fatal cases were recorded [Silva‐Vergara et al, ; Ministry of Health, ] including the three that are reported here.…”

Section: Discussionmentioning

confidence: 99%

Co-circulation in a single biome of the Juquitiba and Araraquara hantavirus detected in human sera in a sub-tropical region of Brazil

et al. 2015

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Hantaviruses is an emerging infectious disease. Although HCPS has been reported in several regions of Brazil, more cases of HCPS have recently been reported in Minas Gerais than in any other state. In 2009, we analyzed 27 samples presenting antibodies against hantaviruses. These samples originated from 688 symptomatic patients, as determined based on the Hemorrhagic Fever Protocol. A subsequent SYBR Green-based real-time RT-PCR demonstrated the presence of the virus in 22 of the samples. Among the RT-PCR-positive samples, 17 were analyzed using DNA sequencing; these sequences were compared with others deposited in GenBank and showed similarity with the Araraquara and Juquitiba virus clusters. This work describe the detection of Juquitiba virus, including three fatal cases, in Minas Gerais state, furthermore, showed that it is feasible to characterize the circulating strains using a small fragment of S segment. Finally, the results suggest the co-circulation of Araraquara and Juquitiba virus in a single biome in Minas Gerais state.

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Hantavirus pulmonary syndrome in Uberaba, Minas Gerais, Brazil

Cited by 10 publications

References 10 publications

A Global Perspective on Hantavirus Ecology, Epidemiology, and Disease

A Global Perspective on Hantavirus Ecology, Epidemiology, and Disease

Twenty years of hantavirus pulmonary syndrome in Brazil: a review of epidemiological and clinical aspects

Co-circulation in a single biome of the Juquitiba and Araraquara hantavirus detected in human sera in a sub-tropical region of Brazil

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