Medicinal products: regulation of biosynthesis in space and time

Gottlieb, Otto R.; Borin, Maria Renata de M. B.

doi:10.1590/s0074-02762000000100019

Cited by 14 publications

(10 citation statements)

References 13 publications

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“…3A) [5][6][7][8]. Substitutions among these categories demonstrate that this evolutionary process operates in countercurrent to the biosynthetic sequence, i.e., by successive step-by-step shortening of the shikimate pathway toward replacement by acetate derivatives ("evolutionary channeling") [9].…”

Section: Phytochemistry: Quantitative Modelmentioning

confidence: 99%

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Quantitative chemobiology

Gottlieb

Borin

Brito

2001

Pure and Applied Chemistry

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Abstract:One of the mysteries of man's contact with nature concerns the question why shamanism and science so often lead to consistent results in the search for useful natural products. To find clues toward an answer via a coherent chemobiological language, structural and functional information is taken into account. The functional information, given by ethnobotanical codes based on traditional knowledge (via number of useful dicotyledon species), is confronted with the structural information, given by metabolic codes based on micromolecular diversification (via number of occurrences in dicotyledons). The challenge to integrate these databases implies in the development of qualitative (via dahlgrenograms) and quantitative (via Sporne indices) models into an evolutionary framework. The follow-up of ethnobotanical qualifications reveals systematic and evolutionary patterns, susceptible to juxtaposition into a phytochemical background based on gallates (GAL) and caffeates (CAF), regulators of intermediate metabolism.Comparison of the two models of information suggests that the "spectral" features of the GAL and CAF-models are coincident with the ethnobotany-guided food-and medicine-plants respectively. Hence, the complementary nature of food and medicine species can be rationalized by oscillations between GAL/CAF. Analyses of these indicators of toxicity would allow advances in the understanding of mechanisms regulating the production of bioactive products.

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Section: Phytochemistry: Quantitative Modelmentioning

confidence: 99%

“…4). This occurs because in spite of decrease in astringency, the GAL concentration is still sufficiently high to cause the inhibitory effect on micromolecular diversity [8,12,[14][15][16][17] and hence, toxicity remains. For database see [11,12].…”

Section: Ethnobotany Vs Phytochemistry: Quantitative Modelmentioning

confidence: 99%

Quantitative chemobiology

Gottlieb

Borin

Brito

2001

Pure and Applied Chemistry

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“…According to this idea, plants occurring at the frontier between two different types of forest could be stimulated to amplify their own production and storage of defensive secondary metabolites, due to the greater number of environmental influences. [19][20][21] In this study, the major secondary metabolites in L. ericoides leaf extracts were characterised by means of HPLC-DAD-MS/MS. 22 Specimens from different environments were analysed using this technique, leading to the establishment of secondary metabolite chemical profiles.…”

Section: Introductionmentioning

confidence: 99%

Differential metabolic and biological profiles of Lychnophora ericoides mart. (Asteraceae) from different localities in the Brazilian "campos rupestres"

Gobbo‐Neto

Guaratini

Pessoa

et al. 2010

J. Braz. Chem. Soc.

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Este artigo descreve a caracterização por CLAE-DAD-EM/EM e CLAE-DEC dos perfis de metabólitos secundários de extratos das folhas de Lychnophora ericoides Mart. de diferentes procedências e suas propriedades citotóxicas e antioxidantes. Extratos foliares de populações representando sete diferentes localidades foram avaliados quanto à atividade antioxidante pelo sistema DPPH e à atividade citotóxica em três linhagens tumorais. Os extratos foram eletroquimicamente caracterizados por CLAE-DEC e seus metabólitos secundários majoritários foram identificados por CLAE-DAD-EM e CLAE-DAD-EM/EM. Um metabolismo secundário defensivo amplificado, juntamente com as mais altas bioatividades antioxidantes e citotóxicas, foi encontrado para as plantas coletadas na interface entre dois tipos de vegetação. Estes resultados fornecem apoio adicional para a hipótese de que plantas ocorrendo na interface entre dois ecossistemas podem ser estimuladas a amplificar sua produção e armazenamento de metabólitos secundários defensivos, devido ao maior número de influências ambientais. This paper reports HPLC-DAD-MS/MS and HPLC-ECD characterisation of secondary metabolite profiles of Lychnophora ericoides Mart. leaf extracts from different provenances and their cytotoxic and antioxidant properties. Leaf extracts from populations representing seven different locations were evaluated for antioxidant activity by the DPPH radical scavenging system and activity towards cellular growth in three tumor cell lines. The extracts were electrochemically analysed by HPLC-ECD and their main secondary metabolites were identified by HPLC-DAD-MS and HPLC-DAD-MS/MS. An amplified defensive secondary chemistry, together with maximal cytotoxic and antioxidant bioactivities, were found for plants collected at the interface between two types of forest. These findings furnish additional support for the hypothesis that plants occurring at the interface between two forests ecosystems might be stimulated to amplify their own production and storage of defensive secondary metabolites due to the greater number of environmental influences.Keywords: Lychnophora ericoides, secondary metabolite infra-specific variation, hyphenated techniques, cytotoxic activity, antioxidant activity IntroductionThe genus Lychnophora (Asteraceae, Vernonieae) is restricted to the Brazilian "cerrado", the Brazilian savannas.1,2 Traditional medicine employs alcohol and water-alcohol preparations of leaves and root powder from several Lychnophora species for the treatment of wounds, inflammation and pain. 3,4 Among Lychnophora species, L. ericoides Mart. is the most widely used in traditional medicine. 3,4 This species occurs in small and well delimited Gobbo-Neto et al. 751 Vol. 21, No. 4, 2010 microendemic populations, usually containing between 20-50 adult individuals in a 100-200 m 2 area, and occurring in a particular type of high altitude, rocky field found in the Brazilian "cerrado". These fields are known as "campos rupestres". 1 Previous phytochemical investigation of L. ericoides le...

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“…The choice of phytochemical data was based on our previous results demonstrating the fundamental importance of gallic and caffeic acids as metabolic regulators. [32][33][34] The "spectral" features of the gallic-model were similar to the "spectral" features of the ethnobotany-guided food plants. In contradistinction, the analogous features of the caffeic-model were similar to the features of the ethnobotany-guided medicine plants.…”

Section: Phytochemistry: Regulatory Mechanisms Of Plant Bioactivitymentioning

confidence: 68%

Quantitative chemobiology: a guide into the understanding of plant bioactivity

Gottlieb¹,

Borin²

2002

J. Braz. Chem. Soc.

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Hoje, nada é mais importante para a sobrevivência humana do que compreender os mecanismos da natureza através de uma linguagem químico-biológica. Essa abordagem multidisciplinar é uma complexa operação, pois envolve a integração de vários níveis de organização, tais como química, morfologia e ecogeografia, expressos respectivamente pela diversificação de metabolitos, formas e ambientes. A comparação entre essas diferentes expressões da vida, apesar de sua importância incontestável, ainda permanece um árduo tópico de pesquisa. Aplicação dessa abordagem unificada poderia revigorar o estudo de um assunto antigo e controvertido, a bioatividade vegetal. Enfrentar o maior desafio desse propósito: confrontar o conhecimento tradicional com uma metodologia científica, requer a determinação de tendências entre usos de espécies de angiospermas, independentemente de empirismos e regionalismos. Assim, incorporação de novos códigos, expressando funções biológicas, na linguagem químico-biológica é possível somente através de conceitos e padrões evolutivos.Nothing is more important for human survival today, than understanding nature's mechanisms via a chemo-biological language. This multidisciplinary approach is a complex operation, because it involves integration of several levels of organization, such as chemistry, morphology and ecogeography, expressed by diversification of metabolites, forms and environments, respectively. A comparison among these different expressions of life, in spite of undisputed importance, still remains an arduous research topic. Application of this unified approach would revigorate the study of old and controversial matter, plant bioactivity. To face the major challenge toward this aim: confrontation of traditional knowledge with scientific methodology, required the determination of trends among the uses of angiosperm species independently of empiricisms and regionalities. Thus, incorporation of new codes, expressing biological functions, in the chemo-biological language becomes possible only through evolutionary concepts and patterns.

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Medicinal products: regulation of biosynthesis in space and time

Abstract: We live in a " Demon-Haunted World". Human

Cited by 14 publications

References 13 publications

Quantitative chemobiology

Quantitative chemobiology

Differential metabolic and biological profiles of Lychnophora ericoides mart. (Asteraceae) from different localities in the Brazilian "campos rupestres"

Quantitative chemobiology: a guide into the understanding of plant bioactivity

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