Populational heterogeneity of Brazilian Trypanosoma cruzi isolates revealed by the mini-exon and ribosomal spacers

Variability of Kinetoplast DNA Gene Signatures of Trypanosoma cruzi II Strains from Patients with Different Clinical Forms of Chagas' Disease in Brazil

“…Our findings are in agreement with previously published data from other Brazilian areas where the disease is endemic and where T. cruzi II is mainly distributed in the domestic cycle and is associated with severe human infections (8,38). Furthermore, the presence of T. cruzi II in cardiac and megaesophagus lesions of distinct chagasic patients was recently demonstrated (10).…”

Trypanosoma cruzi Infection Induces a Global Host Cell Response in Cardiomyocytes

“…In fact, clone Dm28c, used in this study, is a TCI lineage isolate, whereas the strains Y and Brazil, which were used in the previous experiments cited, are TCII lineage isolates. Although TCI and TCII isolates cause similar diseases, the diseases that they cause exhibit many biological, physiological, and pathogenic differences, including different host cell responses (14), and they have different mechanisms of invasion (23,58).…”

Implications of genetic variability of Trypanosoma cruzi for the pathogenesis of Chagas disease

“…In Brazil, T. cruzi I appears to be found preferentially in the wild cycle of Chagas disease transmission, while T. cruzi II is heavily associated with the domiciliary cycle 36 . This was confirmed recently by the demonstration of T. cruzi group II parasites infecting human tissues (esophagus, heart, and colon) in 25 patients with the cardiac or gastrointestinal forms of the disease residing in various cities in the State of Minas Gerais 37 .…”