Zinc Sulphate in the Treatment of Cutaneous Leishmaniasis: an in Vitro and Animal Study

Najim, Rafid A.; Sharquie, Khalifa E.; Farjou, Imad B

doi:10.1590/s0074-02761998000600025

Cited by 34 publications

(31 citation statements)

References 17 publications

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“…The results showed that the two forms of both strains were sensitive to ZS and their respective LD 50 were lower compared to the pentavalent antimony compound. To confirm the results, they administered oral ZS to the mice with CL and they found the positive effects of oral ZS in the treatment of CL lesions (Najim 1998).…”

Section: Discussionmentioning

confidence: 83%

Comparison between intralesional injection of zinc sulfate 2 % solution and intralesional meglumine antimoniate in the treatment of acute old world dry type cutaneous leishmaniasis: a randomized double-blind clinical trial

et al. 2014

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Zinc sulfate (ZS) has been used for the treatment of acute cutaneous leishmaniasis (CL) in both forms of in vivo and in vitro recently. The aim of the present study was to compare the efficacy of intralesional injection of ZS 2 % solution with intralesional glucantime in the treatment of acute CL. In this double-blind randomized clinical trial, 80 cases with acute old world dry type CL were enrolled in the study. The treatment protocol in the first group consisted of intralesional injection of ZS 2 % vials once a week for 10 weeks or sooner in case of complete resolution of the lesions. In the second group, intralesional glucantime once a week for 10 weeks or sooner in case of complete resolution of the lesions were used. In both groups cryotherapy was performed once every other week for 10 weeks. In ZS versus second group, partial and complete clinical response was observed with fewer injections although this difference was not statistically significant. In addition, we found that the trend of treatment in second group was faster but again it was not significant [partial treatment: hazard ratio (HR) 1.4, 95 % CI 0.7-2.9; complete treatment: HR 1.3, 95 % CI 0.6-2.8].The results of this study showed that the intralesional injection of ZS 2 % solution was as effective as glucantime on the healing of the acute old world dry type CL.

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Section: Discussionmentioning

confidence: 83%

Comparison between intralesional injection of zinc sulfate 2 % solution and intralesional meglumine antimoniate in the treatment of acute old world dry type cutaneous leishmaniasis: a randomized double-blind clinical trial

et al. 2014

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“…One of the most common anti-leishmanial therapies during last decades are pentavalent antimonials (Glucantime). But their usefulness has limited by cardiotoxicity and hepatotoxicity (Najim et al 1998). …”

Section: Introductionmentioning

confidence: 99%

Topical terbinafine in the treatment of cutaneous leishmaniasis: triple blind randomized clinical trial

et al. 2015

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Leishmaniasis is a spectrum of disease condition with considerable health impacts, caused by different species of Leishmania. This disease is currently endemic in 98 countries and territories in the world. There are many treatment modalities for cutaneous leishmaniasis. The use of topical terbinafine in the treatment of cutaneous leishmaniasis has recently been considered. Eighty-eight participants more than two years old with proven acute CL by a positive direct smear were randomly allocated to one of the two study arms: first group received meglumine antimoniate (Glucantime) 20 mg/kg/day intramuscular injection (IM) plus a placebo ointment (Mahan Vaseline) for 20 days. The second group received meglumine antimoniate (Glucantime) 20 mg/kg/day IM plus topical terbinafine, for 20 days and were monitored closely by dermatologist during the course of the study. Crude regression analysis showed that there was no significant difference between placebo and intervention group regarding partial or complete treatment (partial treatment: HR crude = 1.1, CI 95 % = 0.7-1.7; complete treatment: HR crude = 1.1, CI 95 % = 0.8-1.7). Although, there was no statistically significant different between the two treatment groups, but clinically it seems that the treatment rate in those who receive glucantime plus terbinafine was more effective than the other group. However this rate depended on the type of lesions. As data indicated ulcerated nodules, papules and plaque in experimental group have been completely improved two times faster than placebo group. Ulcerated nodules, nodules and plaque were partially improved faster in those used tebinafine than placebo ointment.

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“…Although it is effective but they are expensive and may cause serious side effects [24]. Other systemic drugs that were used in treatment of CL like oral zinc sulfate, [4] [5] amphotericin B [9], rifampicin [25], antifungal agents [26]- [31], levamisole [32], dapsone [33] [34]. So the aim of present work is to use topical zinc sulphate rather than intralesional, as a simple non invasive mode of therapy for the patients, and to be compared with well-established topical therapy like 25% topical podophyllin sol [16].…”

Section: Discussionmentioning

confidence: 99%

“…Local infiltration of drug have the advantage of direct effect on parasite due to chemical and osmotic mechanisms such as intralesional sodium stibogluconate antimony [7] and intralesional hypertonic sodium chloride solution (7%) [8], while intralesional zinc sulphate 2% didn't act as osmotic effect, when zinc sulphate was added to axenic amastigotes of both species of Leishmania it caused immediate death. There was no change in the shape of either forms with zinc sulphate, in contrast to 7% hypertonic saline that caused parasite shrinkage beside sudden paralysis [9]. Physical methods have also been tried with success such as microwave thermotherapy [10], CO 2 laser [11], Cryotherapy [12].…”

Section: K E Sharquie Et Almentioning

confidence: 99%

Topical Therapy of Acute Cutaneous Leishmaniasis Using Zinc Sulphate Solution 25% versus Podophyllin Solution 25%

Sharquie¹,

Noaimi²,

Sharara³

et al. 2017

JCDSA

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Background: Zinc sulphate as intralesional and oral therapy was used as a successful therapy in treatment of cutaneous leishmaniasis while 25% topical podophyllin is now commonly used in the treatment of cutaneous leishmaniasis. Objective: To treat acute cutaneous leishmaniasis using topical zinc sulphate solution 25% to be compared with topical podophyllin solution 25%.Patients and Methods: This is a single, blind, interventional, comparative study done in the Department of Dermatology, Baghdad Teaching Hospital, Baghdad, Iraq during the period from January 2015 to June 2015. Forty patients with a total 88 lesions of acute cutaneous leishmaniasis were enrolled in this study; 54 (61.36%) were dry lesions and 34 (38.6%) were ulcerative type. The duration of lesions ranged from 2 -11 (7.7 + 2.483) weeks. The size of the lesions ranged from 0.3 to 8 (2.13 ± 1.53) cm. There were 21 females and 19 males, female to male ratio (1.1:1) and their ages ranged from 1 to 60 (25.92 ± 16.59) years. Diagnosis was confirmed by tissue smear and histopathology. Lesions were divided into two groups with matching types and sizes, and scored according to Sharquie modified Leishmania score to assess the objective response to the topical or systemic therapy and then during follow up responses were graded into mild, moderate, marked response and complete clearance. Group A treated with topical 25% podophyllin solution once weekly for a maximum of 6 weeks, while group B was treated with topical 25% zinc sulphate solution twice daily for 6 weeks. Follow up was every 2 weeks during therapy, and once monthly for 3 months after therapy. Results: A total of 40 patients with clinical diagnosis of acute cutaneous leishmaniasis were included in this study, with a total of 88 lesions. Fifteen (37.50%) patients had Conclusion: Topical zinc sulphate 25% is an effective simple non-invasive non-costly safe topical therapy for cutaneous leishmaniasis and without any contraindications for its use and free of side effects and was as effective as topical podophyllin.

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Zinc Sulphate in the Treatment of Cutaneous Leishmaniasis: an in Vitro and Animal Study

Cited by 34 publications

References 17 publications

Comparison between intralesional injection of zinc sulfate 2 % solution and intralesional meglumine antimoniate in the treatment of acute old world dry type cutaneous leishmaniasis: a randomized double-blind clinical trial

Comparison between intralesional injection of zinc sulfate 2 % solution and intralesional meglumine antimoniate in the treatment of acute old world dry type cutaneous leishmaniasis: a randomized double-blind clinical trial

Topical terbinafine in the treatment of cutaneous leishmaniasis: triple blind randomized clinical trial

Topical Therapy of Acute Cutaneous Leishmaniasis Using Zinc Sulphate Solution 25% versus Podophyllin Solution 25%

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